Hypericin, a Naphthodianthrone Derivative, Prevents Methylglyoxal-Induced Human Endothelial Cell Dysfunction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Do, Moon Ho | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.date.available | 2020-02-27T19:42:32Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-03-01 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6324 | - |
dc.description.abstract | Methylglyoxal (MGO) is a highly reactive metabolite of glucose which is known to cause damage and induce apoptosis in endothelial cells. Endothelial cell damage is implicated in the progression of diabetes-associated complications and atherosclerosis. Hypericin, a naphthodianthrone isolated from Hypericum perforatum L. (St. John's Wort), is a potent and selective inhibitor of protein kinase C and is reported to reduce neuropathic pain. In this work, we investigated the protective effect of hypericin on MGO-induced apoptosis in human umbilical vein endothelial cells (HUVECs). Hypericin showed significant anti-apoptotic activity in MGO-treated HUVECs. Pretreatment with hypericin significantly inhibited MGO-induced changes in cell morphology, cell death, and production of intracellular reactive oxygen species. Hypericin prevented MGO-induced apoptosis in HUVECs by increasing Bcl-2 expression and decreasing Bax expression. MGO was found to activate mitogen-activated protein kinases (MAPKs). Pretreatment with hypericin strongly inhibited the activation of MAPKs, including P38, JNK, and ERK1/2. Interestingly, hypericin also inhibited the formation of AGEs. These findings suggest that hypericin may be an effective regulator of MGO-induced apoptosis. In conclusion, hypericin downregulated the formation of AGEs and ameliorated MGO-induced dysfunction in human endothelial cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.subject | GLYCATION END-PRODUCTS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | ANTIOXIDANT ACTIVITY | - |
dc.subject | AERIAL PARTS | - |
dc.subject | IN-VITRO | - |
dc.subject | ACTIVATION | - |
dc.subject | PERFORATUM | - |
dc.subject | EXTRACTS | - |
dc.subject | ACIDS | - |
dc.title | Hypericin, a Naphthodianthrone Derivative, Prevents Methylglyoxal-Induced Human Endothelial Cell Dysfunction | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000395615300008 | - |
dc.identifier.doi | 10.4062/biomolther.2016.034 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.25, no.2, pp.158 - 164 | - |
dc.identifier.kciid | ART002199189 | - |
dc.identifier.scopusid | 2-s2.0-85015959520 | - |
dc.citation.endPage | 164 | - |
dc.citation.startPage | 158 | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Do, Moon Ho | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Advanced glycation end products | - |
dc.subject.keywordAuthor | Methylglyoxal | - |
dc.subject.keywordAuthor | HUVECs | - |
dc.subject.keywordAuthor | Hypericin | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordPlus | GLYCATION END-PRODUCTS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | AERIAL PARTS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PERFORATUM | - |
dc.subject.keywordPlus | EXTRACTS | - |
dc.subject.keywordPlus | ACIDS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.