Sustained uremic toxin control improves renal and cardiovascular outcomes in patients with advanced renal dysfunction: post-hoc analysis of the Kremezin Study against renal disease progression in Korea
DC Field | Value | Language |
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dc.contributor.author | Cha, Ran-hui | - |
dc.contributor.author | Kang, Shin Wook | - |
dc.contributor.author | Park, Cheol Whee | - |
dc.contributor.author | Cha, Dae Ryong | - |
dc.contributor.author | Na, Ki Young | - |
dc.contributor.author | Kim, Sung Gyun | - |
dc.contributor.author | Yoon, Sun Ae | - |
dc.contributor.author | Kim, Sejoong | - |
dc.contributor.author | Han, Sang Youb | - |
dc.contributor.author | Park, Jung Hwan | - |
dc.contributor.author | Chang, Jae Hyun | - |
dc.contributor.author | Lim, Chun Soo | - |
dc.contributor.author | Kim, Yon Su | - |
dc.date.available | 2020-02-27T19:42:42Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6337 | - |
dc.description.abstract | Background: We investigated the long-term effect of AST-120, which has been proposed as a therapeutic option against renal disease progression, in patients with advanced chronic kidney disease (CKD). Methods: We performed post-hoc analysis with a per-protocol group of the K-STAR study (Kremezin study against renal disease progression in Korea) that randomized participants into an AST-120 and a control arm. Patients in the AST-120 arm were given 6 g of AST-120 in three divided doses, and those in both arms received standard conventional treatment. Results: The two arms did not differ significantly in the occurrence of composite primary outcomes (log-rank P = 0.41). For AST-120 patients with higher compliance, there were fewer composite primary outcomes: intermediate tertile hazard ratio (HR) 0.62, 95% confidence interval (CI) 0.38 to 1.01, P = 0.05; highest tertile HR 0.436, 95% CI 0.25 to 0.76, P = 0.003. The estimated glomerular filtration rate level was more stable in the AST-120 arm, especially in diabetic patients. At one year, the AST-120-induced decrease in the serum indoxyl sulfate concentration inversely correlated with the occurrence of composite primary outcomes: second tertile HR 1.59, 95% CI 0.82 to 3.07, P = 0.17; third tertile HR 2.11, 95% CI 1.07 to 4.17, P = 0.031. Furthermore, AST-120 showed a protective effect against the major cardiovascular adverse events (HR 0.51, 95% CI 0.26 to 0.99, P = 0.046). Conclusion: Long-term use of AST-120 has potential for renal protection, especially in diabetic patients, as well as cardiovascular benefits. Reduction of the serum indoxyl sulfate level may be used to identify patients who would benefit from AST-120 administration. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER INC | - |
dc.relation.isPartOf | KIDNEY RESEARCH AND CLINICAL PRACTICE | - |
dc.subject | CHRONIC KIDNEY-DISEASE | - |
dc.subject | INDOXYL SULFATE | - |
dc.subject | ORAL ADSORBENT | - |
dc.subject | DIABETIC-NEPHROPATHY | - |
dc.subject | PREDIALYSIS PATIENTS | - |
dc.subject | KAPPA-B | - |
dc.subject | AST-120 | - |
dc.subject | FAILURE | - |
dc.subject | EXPRESSION | - |
dc.subject | SORBENT | - |
dc.title | Sustained uremic toxin control improves renal and cardiovascular outcomes in patients with advanced renal dysfunction: post-hoc analysis of the Kremezin Study against renal disease progression in Korea | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000425053400009 | - |
dc.identifier.doi | 10.23876/j.krcp.2017.36.1.68 | - |
dc.identifier.bibliographicCitation | KIDNEY RESEARCH AND CLINICAL PRACTICE, v.36, no.1, pp.68 - 77 | - |
dc.identifier.kciid | ART002212941 | - |
dc.identifier.scopusid | 2-s2.0-85034827920 | - |
dc.citation.endPage | 77 | - |
dc.citation.startPage | 68 | - |
dc.citation.title | KIDNEY RESEARCH AND CLINICAL PRACTICE | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Chang, Jae Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Advanced renal dysfunction | - |
dc.subject.keywordAuthor | AST-120 | - |
dc.subject.keywordAuthor | Cardiovascular outcome | - |
dc.subject.keywordAuthor | Renal outcome | - |
dc.subject.keywordAuthor | Uremic toxin | - |
dc.subject.keywordPlus | CHRONIC KIDNEY-DISEASE | - |
dc.subject.keywordPlus | INDOXYL SULFATE | - |
dc.subject.keywordPlus | ORAL ADSORBENT | - |
dc.subject.keywordPlus | DIABETIC-NEPHROPATHY | - |
dc.subject.keywordPlus | PREDIALYSIS PATIENTS | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | AST-120 | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SORBENT | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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