Defective natural killer cell activity in a mouse model of eczema herpeticum
DC Field | Value | Language |
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dc.contributor.author | Kawakami, Yuko | - |
dc.contributor.author | Ando, Tomoaki | - |
dc.contributor.author | Lee, Jong-Rok | - |
dc.contributor.author | Kim, Gisen | - |
dc.contributor.author | Kawakami, Yu | - |
dc.contributor.author | Nakasaki, Tae | - |
dc.contributor.author | Nakasaki, Manando | - |
dc.contributor.author | Matsumoto, Kenji | - |
dc.contributor.author | Choi, Youn Soo | - |
dc.contributor.author | Kawakami, Toshiaki | - |
dc.date.available | 2020-02-27T19:42:44Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6342 | - |
dc.description.abstract | Background: Patients with atopic dermatitis (AD) are susceptible to several viruses, including herpes simplex virus (HSV). Some patients experience 1 or more episodes of a severe skin infection caused by HSV termed eczema herpeticum (EH). There are numerous mouse models of AD, but no established model exists for EH. Objective: We sought to establish and characterize a mouse model of EH. Methods: We infected AD-like skin lesions with HSV1 to induce severe skin lesions in a dermatitis-prone mouse strain of NC/Nga. Gene expression was investigated by using a microarray and quantitative PCR; antibody titers were measured by means of ELISA; and natural killer (NK) cell, cytotoxic T-cell, regulatory T-cell, and follicular helper T-cell populations were evaluated by using flow cytometry. The role of NK cells in HSV1-induced development of severe skin lesions was examined by means of depletion and adoptive transfer. Results: InoculationofHSV1inducedsevereerosiveskinlesionsin eczematousmice, which had an impaired skinbarrier, butmilder lesionsinsmallnumbersofnormalmice. Eczematousmiceexhibited lowerNKcellactivitybutsimilarcytotoxicT-cellactivityand humoralimmuneresponsescomparedwithnormalmice. Theroleof NKcellsincontrollingHSV1-inducedskinlesionswasdemonstrated byexperimentsdepletingortransferringNKcells. Conclusion: A murine model of EH with an impaired skin barrier was established in this study. We demonstrated a critical role of defective NK activities in the development of HSV1induced severe skin lesions in eczematous mice. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.subject | REGULATORY T-CELLS | - |
dc.subject | ATOPIC-DERMATITIS | - |
dc.subject | NK CELLS | - |
dc.subject | IN-VIVO | - |
dc.subject | IMMUNE DYSREGULATION | - |
dc.subject | GENOME SEQUENCE | - |
dc.subject | VIRUS | - |
dc.subject | DISEASE | - |
dc.subject | PROTEIN | - |
dc.subject | FOXP3 | - |
dc.title | Defective natural killer cell activity in a mouse model of eczema herpeticum | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000397295800031 | - |
dc.identifier.doi | 10.1016/j.jaci.2016.06.034 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, v.139, no.3, pp.997 - + | - |
dc.identifier.scopusid | 2-s2.0-84994388923 | - |
dc.citation.endPage | + | - |
dc.citation.startPage | 997 | - |
dc.citation.title | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.citation.volume | 139 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Rok | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | eczema herpeticum | - |
dc.subject.keywordAuthor | herpes simplex virus | - |
dc.subject.keywordAuthor | animal model | - |
dc.subject.keywordAuthor | natural killer cell | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | NK CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | IMMUNE DYSREGULATION | - |
dc.subject.keywordPlus | GENOME SEQUENCE | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | FOXP3 | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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