Relationship Between K-trans and K-1 with Simultaneous Versus Separate MR/PET in Rabbits with VX2 Tumors
- Authors
- Lee, Kyung Hee; Kang, Seung Kwan; Goo, Jin Mo; Lee, Jae Sung; Cheon, Gi Jeong; Seo, Seongho; Hwang, Eui Jin
- Issue Date
- Mar-2017
- Publisher
- INT INST ANTICANCER RESEARCH
- Keywords
- MR/PET; dynamic contrast enhanced-MRI; N-13-NH3 PET; perfusion parameter; rabbit
- Citation
- ANTICANCER RESEARCH, v.37, no.3, pp.1139 - 1148
- Journal Title
- ANTICANCER RESEARCH
- Volume
- 37
- Number
- 3
- Start Page
- 1139
- End Page
- 1148
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6355
- DOI
- 10.21873/anticanres.11427
- ISSN
- 0250-7005
- Abstract
- Background/Aim: To compare the relationship between Ktrans from DCE-MRI and K1 from dynamic (NNH3)-N-13- PET, with simultaneous and separate MR/PET in the VX-2 rabbit carcinoma model. Materials and Methods: MR/PET was performed simultaneously and separately, 14 and 15 days after VX-2 tumor implantation at the paravertebral muscle. The Ktrans and K-1 values were estimated using an in-house software program. The relationships between Ktrans and K-1 were analyzed using Pearson's correlation coefficients and linear/non-linear regression function. Results: Assuming a linear relationship, Ktrans and K-1 exhibited a moderate positive correlations with both simultaneous ( r=0.54-0.57) and separate ( r=0.53-0.69) imaging. However, while the Ktrans and K-1 from separate imaging were linearly correlated, those from simultaneous imaging exhibited a non-linear relationship. The amount of change in K-1 associated with a unit increase in Ktrans varied depending on Ktrans values. Conclusion: The relationship between K-trans and K-1 may be mis-interpreted with separate MR and PET acquisition.
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