Chitosan-ceramide coating on gold nanorod to improve its physiological stability and reduce the lipid surface-related toxicity
DC Field | Value | Language |
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dc.contributor.author | Battogtokh, Gantumur | - |
dc.contributor.author | Gotov, Oyuntuya | - |
dc.contributor.author | Ko, Young Tag | - |
dc.date.available | 2020-02-27T19:43:12Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6377 | - |
dc.description.abstract | Gold nanoparticles are promising materials for many applications that include imaging, drug delivery, and photothermal therapy. However, AuNPs can be unstable and/or toxic. We purposed to improve the stability and reduce toxicity of gold nanorods (AuNR) upon coating with biocompatible polymer, chitosan-ceramide (CS-CE), without replacing the original layer, CTAB. CS-CE-coated AuNR was prepared by simple mixing for 24 h and purified by centrifugation. The coating was confirmed by UV-Vis absorption analysis and surface charge and size measurement. We prepared nanorods with CS or CS-CE coating at two different concentrations (5 and 10% AuNR), the resulting in larger nanorods with a more positive surface-charge than that of AuNR. We investigated the UV-absorption and protein adsorption of the polymer coated nanorods. Based on the protein adsorption, AuNR-CS-CE was found to be more stable under physiological conditions than AuNR-CS. The cell internalization assay revealed that Hela cells internalized higher amounts of AuNR-CS-CE than that of AuNR-CS. Cytotoxicity study revealed that AuNR- CS-CE has lower toxicity than AuNR against HeLa cells. The CS-CE coating improved the stability of AuNR under physiological conditions via the hydrophobic interactions between the AuNR lipid surface and the ceramide anchor in the CS backbone as well as. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | ORAL DELIVERY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | CANCER | - |
dc.subject | FUNCTIONALIZATION | - |
dc.subject | BIOCONJUGATION | - |
dc.subject | PACLITAXEL | - |
dc.subject | THERAPY | - |
dc.subject | MEDIA | - |
dc.title | Chitosan-ceramide coating on gold nanorod to improve its physiological stability and reduce the lipid surface-related toxicity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000398002500008 | - |
dc.identifier.doi | 10.1007/s12272-017-0888-z | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.40, no.3, pp.356 - 363 | - |
dc.identifier.kciid | ART002206045 | - |
dc.identifier.scopusid | 2-s2.0-85009251291 | - |
dc.citation.endPage | 363 | - |
dc.citation.startPage | 356 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 40 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Battogtokh, Gantumur | - |
dc.contributor.affiliatedAuthor | Gotov, Oyuntuya | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Polymer coating | - |
dc.subject.keywordAuthor | Gold nanorod | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordAuthor | Ceramide | - |
dc.subject.keywordAuthor | Colloidal stability | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | ORAL DELIVERY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
dc.subject.keywordPlus | BIOCONJUGATION | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MEDIA | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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