Prognostic significance of PCR-based molecular staging in patients with diffuse large B-cell lymphoma treated with R-CHOP immunochemotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Ja Young | - |
dc.contributor.author | Hong, Junshik | - |
dc.contributor.author | Chun, Kayeong | - |
dc.contributor.author | Jeong, Jihoon | - |
dc.contributor.author | Cho, Hyeongrae | - |
dc.contributor.author | Kim, Kyung Hee | - |
dc.contributor.author | Park, Jinny | - |
dc.contributor.author | Ahn, Jeong Yeal | - |
dc.contributor.author | Park, Pil-Whan | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.date.available | 2020-02-27T19:43:41Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6405 | - |
dc.description.abstract | The prognostic role of detecting clonal immunoglobulin gene rearrangement (IgR) from bone marrow (BM) aspirates was evaluated by BIOMED-2 PCR in 97 patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab-CHOP immunochemotherapy. Sixteen (16.5%) patients had BM involvement (BMI) defined by BM biopsy (MOR+) and 39 (40.2%) had positive IgR (PCR+). Patients with MOR+BMI showed inferior event-free survival (EFS) compared to those with MOR-/PCR- (p<0.001) or those with MOR-/PCR+BMI (p=0.002), while no significant difference in EFS was observed between patients with MOR-/PCR+and those with MOR-/PCR-BMI (p=0.497). Use of the BIOMED-2 for PCR resulted in significant increase in detection of BMI. However, the increased sensitivity by PCR did not translate into improved prediction of prognosis, emphasizing the essential role of histopathological review of trephine biopsy for the detection of BMI. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | LEUKEMIA & LYMPHOMA | - |
dc.subject | BONE-MARROW INVOLVEMENT | - |
dc.subject | IMMUNOGLOBULIN-GENE REARRANGEMENTS | - |
dc.subject | CHEMOTHERAPY PLUS RITUXIMAB | - |
dc.subject | NON-HODGKINS-LYMPHOMA | - |
dc.subject | FOLLICULAR LYMPHOMA | - |
dc.subject | DISEASE | - |
dc.title | Prognostic significance of PCR-based molecular staging in patients with diffuse large B-cell lymphoma treated with R-CHOP immunochemotherapy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000388601000014 | - |
dc.identifier.doi | 10.1080/10428194.2016.1190967 | - |
dc.identifier.bibliographicCitation | LEUKEMIA & LYMPHOMA, v.58, no.2, pp.357 - 365 | - |
dc.identifier.scopusid | 2-s2.0-84995610450 | - |
dc.citation.endPage | 365 | - |
dc.citation.startPage | 357 | - |
dc.citation.title | LEUKEMIA & LYMPHOMA | - |
dc.citation.volume | 58 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Seo, Ja Young | - |
dc.contributor.affiliatedAuthor | Hong, Junshik | - |
dc.contributor.affiliatedAuthor | Chun, Kayeong | - |
dc.contributor.affiliatedAuthor | Jeong, Jihoon | - |
dc.contributor.affiliatedAuthor | Cho, Hyeongrae | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Park, Jinny | - |
dc.contributor.affiliatedAuthor | Ahn, Jeong Yeal | - |
dc.contributor.affiliatedAuthor | Park, Pil-Whan | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | BIOMED-2 | - |
dc.subject.keywordAuthor | bone marrow involvement | - |
dc.subject.keywordAuthor | clonality | - |
dc.subject.keywordAuthor | diffuse large B-cell lymphoma | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordPlus | BONE-MARROW INVOLVEMENT | - |
dc.subject.keywordPlus | IMMUNOGLOBULIN-GENE REARRANGEMENTS | - |
dc.subject.keywordPlus | CHEMOTHERAPY PLUS RITUXIMAB | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | FOLLICULAR LYMPHOMA | - |
dc.subject.keywordPlus | DISEASE | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.