Mitochondrial-targeted photosensitizer-loaded folate-albumin nanoparticle for photodynamic therapy of cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Battogtokh, Gantumur | - |
dc.contributor.author | Ko, Young Tag | - |
dc.date.available | 2020-02-27T19:44:17Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 1549-9634 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6455 | - |
dc.description.abstract | The objective of this study was to develop a mitochondria-targeted photosensitizer (PS) for photodynamic therapy (PDT). Herein, a porphyrin-derivative photosensitizer, pheophorbide-a (PheoA), was conjugated to carboxybutyltriphenylphosphonium (TPP) via a carbodiimide linkage to enhance mitochondrial targeting and TPP-PheoA conjugate was further loaded into folate-cholesteryl albumin (FA-chol-BSA) nanoparticles (NPs) to improve its biocompatibility. Cellular uptake results showed that TPP-PheoA and TPP-PheoA@ FAchol-BSA NPs were readily taken up by B16F10 and HeLa cells. Further in vitro studies exhibited that TPP-PheoA and its nanoparticle primarily accumulate in the mitochondria, greatly generate ROS, lead mitochondrial disruption and cell apoptosis, and have higher phototoxicity against cancer cells. In vivo bioimaging and the in vivo antitumor studies indicated that TPP-PheoA@ FA-chol-BSA NP greatly accumulated in the tumor area and significantly suppress the tumor growth as compared to PheoA@ FA-chol-BSA NP in tumor-bearing mice. Taken together, TPP-PheoA@ FA-chol-BSA NP could be a promising mitochondria-targeted PS for image-guided PDT. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | - |
dc.subject | CELLS IN-VITRO | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | THERAPEUTICS | - |
dc.subject | MEDICINE | - |
dc.subject | UPDATE | - |
dc.subject | AGENTS | - |
dc.subject | ACID | - |
dc.title | Mitochondrial-targeted photosensitizer-loaded folate-albumin nanoparticle for photodynamic therapy of cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000396940200036 | - |
dc.identifier.doi | 10.1016/j.nano.2016.10.014 | - |
dc.identifier.bibliographicCitation | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v.13, no.2, pp.733 - 743 | - |
dc.identifier.scopusid | 2-s2.0-85010410317 | - |
dc.citation.endPage | 743 | - |
dc.citation.startPage | 733 | - |
dc.citation.title | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Photodynamic therapy | - |
dc.subject.keywordAuthor | Mitochondrial targeting | - |
dc.subject.keywordAuthor | Self-assembled nanoparticle | - |
dc.subject.keywordAuthor | Triphenylphosphonium cation | - |
dc.subject.keywordAuthor | Pheophorbide-a | - |
dc.subject.keywordPlus | CELLS IN-VITRO | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.subject.keywordPlus | MEDICINE | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | ACID | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.