Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes
DC Field | Value | Language |
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dc.contributor.author | Chae, Jae Kyoung | - |
dc.contributor.author | Subedi, Lalita | - |
dc.contributor.author | Jeong, Minsun | - |
dc.contributor.author | Park, Yong Un | - |
dc.contributor.author | Kim, Chul Young | - |
dc.contributor.author | Kim, Hakwon | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.date.available | 2020-02-27T19:44:20Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6458 | - |
dc.description.abstract | Gomisin N, one of the lignan compounds found in Schisandra chinensis has been shown to possess anti-oxidative, anti-tumorigenic, and anti-inflammatory activities in various studies. Here we report, for the first time, the anti-melenogenic efficacy of Gomisin N in mammalian cells as well as in zebrafish embryos. Gomisin N significantly reduced the melanin content without cellular toxicity. Although it was not capable of modulating the catalytic activity of mushroom tyrosinase in vitro, Gomisin N downregulated the expression levels of key proteins that function in melanogenesis. Gomisin N downregulated melanocortin 1 receptor (MC1R), adenylyl cyclase 2, microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2). In addition, Gomisin N-treated Melan-A cells exhibited increased p-Akt and p-ERK levels, which implies that the activation of the PI3K/Akt and MAPK/ERK pathways may function to inhibit melanogenesis. We also validated that Gomisin N reduced melanin production by repressing the expression of MITF, tyrosinase, TRP-1, and TRP-2 in mouse and human cells as well as in developing zebrafish embryos. Collectively, we conclude that Gomisin N inhibits melanin synthesis by repressing the expression of MITF and melanogenic enzymes, probably through modulating the PI3K/Akt and MAPK/ERK pathways. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | DECREASES MELANIN SYNTHESIS | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | L-TYROSINE | - |
dc.subject | SKIN | - |
dc.subject | MICROPHTHALMIA | - |
dc.subject | PIGMENTATION | - |
dc.subject | MITF | - |
dc.subject | EXPRESSION | - |
dc.subject | EXTRACT | - |
dc.subject | STIMULATION | - |
dc.title | Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000395457700237 | - |
dc.identifier.doi | 10.3390/ijms18020471 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.18, no.2 | - |
dc.identifier.scopusid | 2-s2.0-85013657170 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Chae, Jae Kyoung | - |
dc.contributor.affiliatedAuthor | Subedi, Lalita | - |
dc.contributor.affiliatedAuthor | Jeong, Minsun | - |
dc.contributor.affiliatedAuthor | Park, Yong Un | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Schisandra chinensis | - |
dc.subject.keywordAuthor | Gomisin N | - |
dc.subject.keywordAuthor | lignan | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | skin whitening | - |
dc.subject.keywordPlus | DECREASES MELANIN SYNTHESIS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | L-TYROSINE | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | MICROPHTHALMIA | - |
dc.subject.keywordPlus | PIGMENTATION | - |
dc.subject.keywordPlus | MITF | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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