Fluorescent Gold Nanoclusters for Selective Detection of Dopamine in Cerebrospinal fluid
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Govindaraju, Saravanan | - |
dc.contributor.author | Ankireddy, Seshadri Reddy | - |
dc.contributor.author | Viswanath, Buddolla | - |
dc.contributor.author | Kim, Jongsung | - |
dc.contributor.author | Yun, Kyusik | - |
dc.date.available | 2020-02-27T19:44:37Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2017-01-09 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6479 | - |
dc.description.abstract | Since the last two decades, protein conjugated fluorescent gold nanoclusters (NCs) owe much attention in the field of medical and nanobiotechnology due to their excellent photo stability characteristics. In this paper, we reported stable, nontoxic and red fluorescent emission BSA-Au NCs for selective detection of L-dopamine (DA) in cerebrospinal fluid (CSF). The evolution was probed by various instrumental techniques such as UV-vis spectroscopy, High resolution transmission electron microscopy (HTEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), photoluminescence spectroscopy (PL). The synthesised BSA-Au NCs were showing 4-6 nm with high fluorescent similar to 8% Quantum yield (QY). The fluorescence intensity of BSA-Au NCs was quenched upon the addition of various concentrations of DA via an electron transfer mechanism. The decrease in BSA-Au NCs fluorescence intensity made it possible to determine DA in PBS buffer and the spiked DA in CSF in the linear range from 0 to 10 nM with the limit of detection (LOD) 0.622 and 0.830 nM respectively. Best of our knowledge, as-prepared BSA-Au NCs will gain possible strategy and good platform for biosensor, drug discovery, and rapid disease diagnosis such as Parkinson's and Alzheimer diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.subject | ASCORBIC-ACID | - |
dc.subject | LUMINESCENT | - |
dc.subject | CLUSTERS | - |
dc.title | Fluorescent Gold Nanoclusters for Selective Detection of Dopamine in Cerebrospinal fluid | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000391370900001 | - |
dc.identifier.doi | 10.1038/srep40298 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7 | - |
dc.identifier.scopusid | 2-s2.0-85008879616 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Govindaraju, Saravanan | - |
dc.contributor.affiliatedAuthor | Ankireddy, Seshadri Reddy | - |
dc.contributor.affiliatedAuthor | Viswanath, Buddolla | - |
dc.contributor.affiliatedAuthor | Kim, Jongsung | - |
dc.contributor.affiliatedAuthor | Yun, Kyusik | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ASCORBIC-ACID | - |
dc.subject.keywordPlus | LUMINESCENT | - |
dc.subject.keywordPlus | CLUSTERS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.