Anti-vascular inflammatory effects of pentacyclic triterpenoids from Astilbe rivularis in vitro and in vivo
DC Field | Value | Language |
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dc.contributor.author | Kang, Hyejin | - |
dc.contributor.author | Ku, Sae-Kwang | - |
dc.contributor.author | Kim, Jongdoo | - |
dc.contributor.author | Chung, Jiwoo | - |
dc.contributor.author | Kim, Sang Chan | - |
dc.contributor.author | Zhou, Wei | - |
dc.contributor.author | Na, MinKyun | - |
dc.contributor.author | Bae, Jong-Sup | - |
dc.date.available | 2020-02-27T19:44:40Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2017-01-05 | - |
dc.identifier.issn | 0009-2797 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6482 | - |
dc.description.abstract | Sepsis is a systemic inflammatory condition resulting from bacterial infections. It is associated with high mortality rates, and its therapeutic options are limited. Transforming growth factor b induced protein (TGFBIp) is an extracellular matrix protein that functions as a mediator of experimental sepsis. C-27carboxylated pentacyclic triterpenoids are specifically found in species of the genus Astilbe, and show several biological effects. Given the anti-inflammatory effects of pentacyclic triterpenoids, we investigated the effects of 3b-trans-p-coumaroyloxy-olean-12-en-27-oic acid (1) and 6b-hydroxy-3-oxoolean12- en-27-oic acid (2) on TGFBIp-mediated vascular inflammatory responses. The anti-inflammatory activities of compounds 1 and 2 were determined by measuring the permeability, leukocyte adhesion and migration, and activation of pro-inflammatory proteins in TGFBIp-activated human umbilical vein endothelial cells (HUVECs) and mice. We found that compounds 1 and 2 inhibited lipopolysaccharide (LPS)-induced TGFBIp secretion, TGFBIp-induced barrier disruption, expression of cell adhesion molecules (CAMs), and the adhesion/transendothelial migration of the neutrophils to the human endothelial cells. Compounds 1 and 2 also suppressed TGFBIp-induced hyperpermeability and leukocyte migration in vivo. These results suggested that C-27-carboxylated pentacyclic triterpenoids 1 and 2 have antiinflammatory functions by inhibiting hyperpermeability, CAM expression, and leukocyte adhesion/migration. Therefore, these compounds can be considered as a potential therapy for vascular inflammatory diseases. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.relation.isPartOf | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.subject | HUMAN ENDOTHELIAL-CELLS | - |
dc.subject | GROWTH-FACTOR-BETA | - |
dc.subject | ADHESION MOLECULE EXPRESSION | - |
dc.subject | ACTIVATED PROTEIN-C | - |
dc.subject | GROUP BOX 1 | - |
dc.subject | ASIATIC ACID | - |
dc.subject | EXPERIMENTAL SEPSIS | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | CECAL LIGATION | - |
dc.subject | ANIMAL-MODELS | - |
dc.title | Anti-vascular inflammatory effects of pentacyclic triterpenoids from Astilbe rivularis in vitro and in vivo | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000390664900015 | - |
dc.identifier.doi | 10.1016/j.cbi.2016.11.014 | - |
dc.identifier.bibliographicCitation | CHEMICO-BIOLOGICAL INTERACTIONS, v.261, pp.127 - 138 | - |
dc.identifier.scopusid | 2-s2.0-84999122160 | - |
dc.citation.endPage | 138 | - |
dc.citation.startPage | 127 | - |
dc.citation.title | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.citation.volume | 261 | - |
dc.contributor.affiliatedAuthor | Kim, Jongdoo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Astilbe rivularis | - |
dc.subject.keywordAuthor | C-27 Carboxylated pentacyclic triterpenoids | - |
dc.subject.keywordAuthor | TGFBIp | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Sepsis | - |
dc.subject.keywordPlus | HUMAN ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | ADHESION MOLECULE EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-C | - |
dc.subject.keywordPlus | GROUP BOX 1 | - |
dc.subject.keywordPlus | ASIATIC ACID | - |
dc.subject.keywordPlus | EXPERIMENTAL SEPSIS | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | CECAL LIGATION | - |
dc.subject.keywordPlus | ANIMAL-MODELS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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