The efficacy of fluoropyrimidine-based adjuvant chemotherapy on biliary tract cancer after R0 resection
DC Field | Value | Language |
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dc.contributor.author | Kim, Young Saing | - |
dc.contributor.author | Jeong, Chi-Young | - |
dc.contributor.author | Song, Haa-Na | - |
dc.contributor.author | Kim, Tae Hyo | - |
dc.contributor.author | Kim, Hong Jun | - |
dc.contributor.author | Lee, Young-Joon | - |
dc.contributor.author | Hong, Soon Chan | - |
dc.date.available | 2020-02-27T19:44:52Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2017-01-13 | - |
dc.identifier.issn | 1000-467X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6497 | - |
dc.description.abstract | Background: The optimal treatment strategy for biliary tract cancer (BTC) after curative-intent resection remains controversial. The purpose of this study was to evaluate the efficacy of fluoropyrimidine-based adjuvant chemotherapy for BTC patients undergoing microscopically margin-negative (R0) resection. Methods: We retrospectively analyzed the clinical data of BTC patients who underwent curative-intent R0 resection. Patients were eligible if they received either fluoropyrimidine-based adjuvant chemotherapy or observation after R0 resection. Results: A total of 153 patients were included. In the entire patient cohort, no significant differences were observed in 5-year overall survival (OS) rates (48.4% vs. 39.6%, P = 0.439) or 3-year recurrence-free survival (RFS) rates (49.1% vs. 39.5%, P = 0.299) between patients who received fluoropyrimi dine-based adjuvant chemotherapy or observation. However, for patients with stages II and III BTC, chemotherapy significantly improved 5-year OS rate (52.4% vs. 35.6%, P = 0.002) and 3-year RFS rate (55.5% vs. 39.1%, P = 0.021) compared with observation. Conclusion: Fluoropyrimidine-based adjuvant chemotherapy may prolong the survival of patients with stages II and III BTC after R0 resection. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SUN YAT SEN UNIV MED SCI WHO | - |
dc.relation.isPartOf | CHINESE JOURNAL OF CANCER | - |
dc.subject | SURGICAL MARGIN STATUS | - |
dc.subject | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject | HILAR CHOLANGIOCARCINOMA | - |
dc.subject | GALLBLADDER CARCINOMA | - |
dc.subject | PROGNOSTIC-FACTORS | - |
dc.subject | GEMCITABINE | - |
dc.subject | SURVIVAL | - |
dc.subject | CHEMORADIATION | - |
dc.subject | THERAPY | - |
dc.subject | ADENOCARCINOMA | - |
dc.title | The efficacy of fluoropyrimidine-based adjuvant chemotherapy on biliary tract cancer after R0 resection | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000397781900001 | - |
dc.identifier.doi | 10.1186/s40880-017-0182-y | - |
dc.identifier.bibliographicCitation | CHINESE JOURNAL OF CANCER, v.36 | - |
dc.identifier.scopusid | 2-s2.0-85016152148 | - |
dc.citation.title | CHINESE JOURNAL OF CANCER | - |
dc.citation.volume | 36 | - |
dc.contributor.affiliatedAuthor | Kim, Young Saing | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Biliary tract cancer | - |
dc.subject.keywordAuthor | Adjuvant chemotherapy | - |
dc.subject.keywordAuthor | Fluoropyrimidine | - |
dc.subject.keywordAuthor | R0 resection | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordPlus | SURGICAL MARGIN STATUS | - |
dc.subject.keywordPlus | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | HILAR CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | GALLBLADDER CARCINOMA | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | GEMCITABINE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CHEMORADIATION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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