The Mixture of Gotu Kola, Cnidium Fruit, and Goji Berry Enhances Memory Functions by Inducing Nerve-Growth-Factor-Mediated Actions Both In Vitro and In Vivo
DC Field | Value | Language |
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dc.contributor.author | Choi J.G. | - |
dc.contributor.author | Khan Z. | - |
dc.contributor.author | Hong S.M. | - |
dc.contributor.author | Kim Y.C. | - |
dc.contributor.author | Oh M.S. | - |
dc.contributor.author | Kim S.Y. | - |
dc.date.available | 2020-07-17T00:35:25Z | - |
dc.date.created | 2020-05-25 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/66278 | - |
dc.description.abstract | Nerve growth factor (NGF), a typical neurotrophin, has been characterized by the regulation of neuronal cell differentiation and survival involved in learning and memory functions. NGF has a main role in neurite extension and synapse formation by activating the cyclic adenosine monophosphate-response-element-binding protein (CREB) in the hippocampus. The purpose of this study was to determine whether a mixture of Gotu Kola, Cnidium fruit, and Goji berry (KYJ) enhances memory function by inducing NGF-mediated actions both in vitro and in vivo. The KYJ combination increased NGF concentration and neurite length in C6 glioma and N2a neuronal cells, respectively. Additionally, we discovered memory-enhancing effects of KYJ through increased NGF-mediated synapse maturation, CREB phosphorylation, and cell differentiation in the mouse hippocampus. These findings suggest that this combination may be a potential nootropic cognitive enhancer via the induction of NGF and NGF-dependent activities. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Nutrients | - |
dc.title | The Mixture of Gotu Kola, Cnidium Fruit, and Goji Berry Enhances Memory Functions by Inducing Nerve-Growth-Factor-Mediated Actions Both In Vitro and In Vivo | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000542272700076 | - |
dc.identifier.doi | 10.3390/nu12051372 | - |
dc.identifier.bibliographicCitation | Nutrients, v.12, no.5 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85084627591 | - |
dc.citation.title | Nutrients | - |
dc.citation.volume | 12 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Khan Z. | - |
dc.contributor.affiliatedAuthor | Hong S.M. | - |
dc.contributor.affiliatedAuthor | Kim S.Y. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cnidium fruit | - |
dc.subject.keywordAuthor | Goji berry | - |
dc.subject.keywordAuthor | Gotu Kola | - |
dc.subject.keywordAuthor | KYJ | - |
dc.subject.keywordAuthor | memory enhancing | - |
dc.subject.keywordAuthor | Nerve growth factor | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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