Elm bark extract improves immunomodulation and ameliorates oxidative stress in irradiated mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Y.-S. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Kim, H.-S. | - |
dc.contributor.author | Lee, H.-J. | - |
dc.date.available | 2020-02-27T20:42:15Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 2352-6181 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6643 | - |
dc.description.abstract | Background Radiation therapy can result in side effects such as cellular and tissue inflammation and organ damage. Previously, elm bark (EB) extract has been reported to exert antioxidant and anti-inflammatory effects. In this study, we investigated whether EB administration could improve immunocompetence and ameliorate radiation-induced intestinal damage in irradiated mice. Methods After exposure to radiation of 15 Gy, mice were orally administered with EB extract (0 mg/kg, 50 mg/kg, and 500 mg/kg body weight) every other day for 2 weeks, and there was a 2-week washout period. The proliferation of splenocytes and cytokine production of macrophage were measured as indices of immune activity, and histological grade and antioxidant levels in radiation-induced intestinal injury were measured. Results Radiation exposure reduced the T-cell proliferation in splenocytes and the levels of interleukin-1β and interleukin-6 from macrophage at Week 2. The supplement of EB extract at low concentration (50 mg/kg body weight; EB-50) tended to enhance T-and B-cell proliferation in irradiated mice. The histological grades of the small intestine were induced by radiation exposure, whereas histological grade of the EB-50 group was lower than that of the irradiated control at Week 4. The EB-50 treatment reduced the level of glutathione at Day 5 and Week 2 and reduced myeloperoxidase activity at Week 4, suggesting that EB-50 may counteract the intestinal inflammation caused by radiation exposure. Conclusion Our results indicate that EB extract (50 mg/kg body weight) protects against radiation damage, at least in part, by improving immunomodulation and ameliorating oxidative stress in irradiated mice. © 2017 Korea Food Research Institute | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isPartOf | Journal of Ethnic Foods | - |
dc.title | Elm bark extract improves immunomodulation and ameliorates oxidative stress in irradiated mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.1016/j.jef.2017.01.001 | - |
dc.identifier.bibliographicCitation | Journal of Ethnic Foods, v.4, no.1, pp.15 - 20 | - |
dc.identifier.kciid | ART002223864 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85013466837 | - |
dc.citation.endPage | 20 | - |
dc.citation.startPage | 15 | - |
dc.citation.title | Journal of Ethnic Foods | - |
dc.citation.volume | 4 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lee, Y.-S. | - |
dc.contributor.affiliatedAuthor | Lee, H.-J. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | elm bark | - |
dc.subject.keywordAuthor | immune system | - |
dc.subject.keywordAuthor | intestinal damage | - |
dc.subject.keywordAuthor | mice | - |
dc.subject.keywordAuthor | radiation | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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