Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: Real-world evidence from the Middle East
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, J. | - |
dc.contributor.author | Novick, D. | - |
dc.contributor.author | Moneta, M.V. | - |
dc.contributor.author | El-Shafei, A. | - |
dc.contributor.author | Dueñas, H. | - |
dc.contributor.author | Haro, J.M. | - |
dc.date.available | 2020-02-27T20:42:40Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1745-0179 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6679 | - |
dc.description.abstract | Background: The Global Burden of Disease 2010 study reported the relative size of major depressive disorder (MDD) burden to be greater in the Middle East and North Africa than anywhere else. However, little research has been carried out to examine the comparative effectiveness of antidepressants in this region. Objective: To assess and compare functioning levels in Middle Eastern patients with MDD treated with either duloxetine or a selective serotonin reuptake inhibitor (SSRI), and to examine the impacts of depression-related pain on functioning by the type of treatment. Method: This post-hoc analysis, which focused on Middle Eastern patients, used data from a 6-month prospective observational study that included 1,549 MDD patients without sexual dysfunction. Levels of functional impairment and depression-related pain were assessed using the Sheehan Disability Scale (SDS) and the modified Somatic Symptom Inventory, respectively. A mixed model with repeated measures (MMRM) was employed. Results: The mean age of the patients was 37.3 (SD=8.4) years, and 34.6% were female. Patient functioning was, on average, moderately impaired at baseline, but improved substantially during follow-up in both the duloxetine (n=152) and the SSRI (n=123) cohorts. The MMRM results showed a lower level of functional impairment at 24 weeks in the duloxetine cohort than in the SSRI cohort (p<0.001). Pain severity at baseline was positively associated with functional impairment during follow-up only in the SSRI cohort (p=0.003). Conclusion: Duloxetine-treated MDD patients achieved better functioning than SSRI-treated patients. This treatment difference was partly driven by depression-related pain. © 2017 Hong et al. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Bentham Science Publishers B.V. | - |
dc.relation.isPartOf | Clinical Practice and Epidemiology in Mental Health | - |
dc.subject | antidepressant agent | - |
dc.subject | benzodiazepine derivative | - |
dc.subject | duloxetine | - |
dc.subject | escitalopram | - |
dc.subject | paroxetine | - |
dc.subject | serotonin uptake inhibitor | - |
dc.subject | sertraline | - |
dc.subject | adult | - |
dc.subject | Article | - |
dc.subject | disease severity | - |
dc.subject | female | - |
dc.subject | follow up | - |
dc.subject | functional disease | - |
dc.subject | human | - |
dc.subject | major clinical study | - |
dc.subject | major depression | - |
dc.subject | male | - |
dc.subject | Middle East | - |
dc.subject | multicenter study (topic) | - |
dc.subject | pain | - |
dc.subject | pain assessment | - |
dc.subject | post hoc analysis | - |
dc.subject | rating scale | - |
dc.subject | Saudi Arabia | - |
dc.subject | Sheehan Disability Scale | - |
dc.subject | Somatic Symptom Inventory | - |
dc.subject | symptomatology | - |
dc.subject | United Arab Emirates | - |
dc.title | Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: Real-world evidence from the Middle East | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.2174/1745017901713010145 | - |
dc.identifier.bibliographicCitation | Clinical Practice and Epidemiology in Mental Health, v.13, pp.145 - 155 | - |
dc.identifier.scopusid | 2-s2.0-85032642984 | - |
dc.citation.endPage | 155 | - |
dc.citation.startPage | 145 | - |
dc.citation.title | Clinical Practice and Epidemiology in Mental Health | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Hong, J. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Antidepressant | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Duloxetine | - |
dc.subject.keywordAuthor | Functioning | - |
dc.subject.keywordAuthor | Middle East | - |
dc.subject.keywordAuthor | SSRI | - |
dc.subject.keywordPlus | antidepressant agent | - |
dc.subject.keywordPlus | benzodiazepine derivative | - |
dc.subject.keywordPlus | duloxetine | - |
dc.subject.keywordPlus | escitalopram | - |
dc.subject.keywordPlus | paroxetine | - |
dc.subject.keywordPlus | serotonin uptake inhibitor | - |
dc.subject.keywordPlus | sertraline | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | disease severity | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | follow up | - |
dc.subject.keywordPlus | functional disease | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | major depression | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | Middle East | - |
dc.subject.keywordPlus | multicenter study (topic) | - |
dc.subject.keywordPlus | pain | - |
dc.subject.keywordPlus | pain assessment | - |
dc.subject.keywordPlus | post hoc analysis | - |
dc.subject.keywordPlus | rating scale | - |
dc.subject.keywordPlus | Saudi Arabia | - |
dc.subject.keywordPlus | Sheehan Disability Scale | - |
dc.subject.keywordPlus | Somatic Symptom Inventory | - |
dc.subject.keywordPlus | symptomatology | - |
dc.subject.keywordPlus | United Arab Emirates | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.