The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형진 | - |
dc.contributor.author | 정윤재 | - |
dc.date.available | 2020-07-20T00:35:47Z | - |
dc.date.created | 2020-07-07 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/67532 | - |
dc.description.abstract | Eosinophils are terminally differentiated cytotoxic effector cells that have a role in parasitic infections and allergy by releasing their granule-derived cytotoxic proteins. However, an increasing number of recent observations indicate that eosinophils are not only associated with the pathogenesis of a wide range of diseases, but also contribute to the maintenance of homeostatic responses in previously underappreciated diverse tissues, such as the gastrointestinal (GI) tract and adipose tissue. In this review, we describe biological characteristics of eosinophils, as their developmental properties, permissive proliferation and survival, degranulation activity, and migration properties enable them to distribute to both homeostatic and inflamed tissues. We describe pathologic aspects of eosinophils with a role in asthma and in various GI diseases, including eosinophilic GI disorders, inflammatory bowel disease, and radiation-induced enteropathy. Finally, we discuss the beneficial role of eosinophils, which contribute to the resolution of pathogenic conditions and to the modulation of homeostatic biologic responses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한면역학회 | - |
dc.relation.isPartOf | Immune Network | - |
dc.title | The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease | - |
dc.title.alternative | The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000546250100005 | - |
dc.identifier.doi | 10.4110/in.2020.20.e24 | - |
dc.identifier.bibliographicCitation | Immune Network, v.20, no.3, pp.1 - 14 | - |
dc.identifier.kciid | ART002606190 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85087563185 | - |
dc.citation.endPage | 14 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Immune Network | - |
dc.citation.volume | 20 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 김형진 | - |
dc.contributor.affiliatedAuthor | 정윤재 | - |
dc.subject.keywordAuthor | Eosinophils | - |
dc.subject.keywordAuthor | Eosinophil granule proteins | - |
dc.subject.keywordAuthor | Hypersensitivity | - |
dc.subject.keywordAuthor | Eosinophilic gastrointestinal disorders | - |
dc.subject.keywordAuthor | Homeostasis | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.