소청룡탕이 파골세포 분화억제와 골흡수에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안민윤 | - |
dc.contributor.author | 임형호 | - |
dc.date.available | 2020-02-27T20:44:32Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1010-0695 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6827 | - |
dc.description.abstract | Objectives: This study was performed to evaluate effects of Sochungryong-tang Extract(SRE) on osteoclast differentiation and bone resorptionin order to find out the possibility for clinical use in preventing and treating osteoporosis. Methods: To evaluate the effect of SRE on osteoclast differentiation, we induced RAW 264. 7 cells to be differentiated to osteoclasts by RANKL (receptor activator of nuclear factor-κB ligand). We measured effect on TRAP (Tartrate-resistant acid phosphatase), NFATc, cathepsin K, MMP-9, inflammation related factors, histogenesis factors and bone resorption. Results: SRE decreased osteoclast differentiation, and also decreased expression of bone resorbing factors such as MMP-9, cathepsin K, TRAP, NFATc1, MITF, c-Fos, osteoclast stimulatory transmembrane protein, calcitonin receptor in RANKL-induced osteoclast. SRE also decreased Cyclooxygenase-2, indusible nitric oxide synthase, TNF-α, which are thought to be related with the inflammatory bone destruction. Conclusion: SRE inhibits osteoclast differentiation and bone resorption. The results indicate that the BHT extract can potentially be applied for preventing and treating osteoporosis. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한한의학회 | - |
dc.relation.isPartOf | 대한한의학회지 | - |
dc.title | 소청룡탕이 파골세포 분화억제와 골흡수에 미치는 영향 | - |
dc.title.alternative | Effect of Sochungryong-tang Extract on Osteoclast Differentiation and Bone-pit Formation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한한의학회지, v.38, no.3, pp.59 - 72 | - |
dc.identifier.kciid | ART002265650 | - |
dc.citation.endPage | 72 | - |
dc.citation.startPage | 59 | - |
dc.citation.title | 대한한의학회지 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 안민윤 | - |
dc.contributor.affiliatedAuthor | 임형호 | - |
dc.subject.keywordAuthor | Sochungryong-tang | - |
dc.subject.keywordAuthor | Osteoclast | - |
dc.subject.keywordAuthor | Bone resorption | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.description.journalRegisteredClass | kci | - |
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