Hypernatremia at admission predicts poor survival in patients with terminal cancer: a retrospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Seo, M.-S. | - |
dc.contributor.author | Hwang, I.C. | - |
dc.contributor.author | Jung, J. | - |
dc.contributor.author | Lee, H. | - |
dc.contributor.author | Choi, J.H. | - |
dc.contributor.author | Shim, J.-Y. | - |
dc.date.available | 2020-07-23T01:35:21Z | - |
dc.date.created | 2020-07-20 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 1472-684X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/68800 | - |
dc.description.abstract | BACKGROUND: Although palliative care providers, patients, and their families rely heavily on accurate prognostication, the prognostic value of electrolyte imbalance has received little attention. METHODS: As a retrospective review, we screened inpatients with terminal cancer admitted between January 2017 and May 2019 to a single hospice-palliative care unit. Clinical characteristics and laboratory results were obtained from medical records for multivariable Cox regression analysis of independent prognostic factors. RESULTS: Of the 487 patients who qualified, 15 (3%) were hypernatremic upon admission. The median survival time was 26 days. Parameters associated with shortened survival included male sex, advanced age (> 70 years), lung cancer, poor performance status, elevated inflammatory markers, azotemia, impaired liver function, and hypernatremia. In a multivariable Cox proportional hazards model, male sex (hazard ratio [HR] = 1.53, 95% confidence interval [CI]: 1.15-2.04), poor performance status (HR = 1.45, 95% CI: 1.09-1.94), leukocytosis (HR = 1.98, 95% CI: 1.47-2.66), hypoalbuminemia (HR = 2.06, 95% CI: 1.49-2.73), and hypernatremia (HR = 1.55, 95% CI: 1.18-2.03) emerged as significant predictors of poor prognosis. CONCLUSION: Hypernatremia may be a useful gauge of prognosis in patients with terminal cancer. Further large-scale prospective studies are needed to corroborate this finding. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | BMC palliative care | - |
dc.title | Hypernatremia at admission predicts poor survival in patients with terminal cancer: a retrospective cohort study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000547007100001 | - |
dc.identifier.doi | 10.1186/s12904-020-00607-z | - |
dc.identifier.bibliographicCitation | BMC palliative care, v.19, no.1, pp.94 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85087640627 | - |
dc.citation.startPage | 94 | - |
dc.citation.title | BMC palliative care | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Hwang, I.C. | - |
dc.contributor.affiliatedAuthor | Jung, J. | - |
dc.contributor.affiliatedAuthor | Lee, H. | - |
dc.contributor.affiliatedAuthor | Choi, J.H. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Electrolyte imbalance | - |
dc.subject.keywordAuthor | Hypernatremia | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Terminal cancer | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
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