금속이온, 킬레이트 화합물과 키토산 혼합물의 항칸디다 상승 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주원 | - |
dc.contributor.author | 김선휘 | - |
dc.contributor.author | 최민 | - |
dc.contributor.author | 김태희 | - |
dc.contributor.author | 이우진 | - |
dc.contributor.author | 김정민 | - |
dc.contributor.author | 이종찬 | - |
dc.contributor.author | 장주영 | - |
dc.contributor.author | 박제권 | - |
dc.date.available | 2020-02-27T21:42:33Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1229-4160 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7012 | - |
dc.description.abstract | The potential of using chitosan as a biological agent for the control of Candida albicans was investigated. A chitosan designated as an active molecular chitosan (AMC) with average molecular weight of 8.5-kDa exhibited an effective and potential anticandidal effect at 100 mg/mL. Although metal ion Zn 2+ and EDTA had shown the significant growth inhibitory activity, but both had also shown the static effect on reversible growth inhibition, respectively, whereas AMC showed irreversible growth inhibition. In addition, anticandidal activity of those metal ions, chelating agent and a classic drug using as anticandidal agent Amphotericin B was greatly increased in the presence of AMC mg/mL. These results suggest that AMC-Zn 2+ - EDTA exerted their activities through dysregulation of the homeostasis or signaling of different cations in anticandidal effect. Thus, the combination of Zn 2+ , chelating agent EDTA and AMC may be an effective disease management strategy to prevent or delay the development of bactericidal-resistant strains. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 한국키틴키토산학회 | - |
dc.relation.isPartOf | Journal of Chitin and Chitosan | - |
dc.title | 금속이온, 킬레이트 화합물과 키토산 혼합물의 항칸디다 상승 효과 | - |
dc.title.alternative | Synergistic Anticandidal Activity of Metal Ions, Chelating Agent and Chitosan | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.17642/jcc.22.2.1 | - |
dc.identifier.bibliographicCitation | Journal of Chitin and Chitosan, v.22, no.2, pp.69 - 75 | - |
dc.identifier.kciid | ART002235545 | - |
dc.citation.endPage | 75 | - |
dc.citation.startPage | 69 | - |
dc.citation.title | Journal of Chitin and Chitosan | - |
dc.citation.volume | 22 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | 김주원 | - |
dc.contributor.affiliatedAuthor | 김선휘 | - |
dc.contributor.affiliatedAuthor | 최민 | - |
dc.contributor.affiliatedAuthor | 김태희 | - |
dc.contributor.affiliatedAuthor | 이우진 | - |
dc.contributor.affiliatedAuthor | 김정민 | - |
dc.contributor.affiliatedAuthor | 이종찬 | - |
dc.contributor.affiliatedAuthor | 박제권 | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordAuthor | Candida albicans | - |
dc.subject.keywordAuthor | EDTA | - |
dc.subject.keywordAuthor | Divalent cations | - |
dc.subject.keywordAuthor | Antibacterial effect | - |
dc.description.journalRegisteredClass | kci | - |
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