Radiolabeling of 11C-sertraline by fast and easy loop method with [11C]CH3OTf
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이학정 | - |
dc.contributor.author | 정재민 | - |
dc.contributor.author | 이상윤 | - |
dc.contributor.author | Tatsuo Ido | - |
dc.date.available | 2020-02-27T21:42:45Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 2384-1583 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7028 | - |
dc.description.abstract | Cis-(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tertrahydro-N-methyl-1-naphthalenamine (sertraline) hydrochloride from among selective serotonin reuptake inhibitors (SSRIs) is a treatment of major depression. For the differential diagnosis by metabolizing serotonin in a patient with neurological disorders, the radiolabeled 11C-sertraline was developed for non-invasive positron emission tomography in living brain and use the evaluation of new drug for SSRIs. We release the results of a fast and easy radiolabeling method applied a one-step loop method with [11C]CH3OTf for routine clinical applications of 11C-sertraline. 1 mg of a precursor for 11C-sertraline in 0.1 mL DMF and 5 μL of 1N NaOH, were injected into the loop of semi-prep high-performance liquid chromatography (HPLC). [11C]CH3OTf was passed through the loop at room temperature (RT). The 11C-sertraline was separated by the semi-preparative HPLC. 11C-sertraline was eluted at 28.0 min was collected and evaluated by analytical HPLC and mass spectrometer. The total radiolabeling efficiency of 11C-sertraline was 30.7±8.7%. The specific activity was 64.8±51.4 GBq/μmol. The radiochemical and chemical purities were higher than 99%. The mass spectrum of the product showed m/z peaks at 307.1 (M+1), indicating the mass of sertraline. By the one-step loop method with [11C]CH3OTf, 11C-sertraline could be quickly and easily prepared for clinical application. J Radiopharm Mol Probes 3(1):32-37, 2017 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한방사성의약품학회 | - |
dc.relation.isPartOf | 대한방사성의약품학회지 | - |
dc.title | Radiolabeling of 11C-sertraline by fast and easy loop method with [11C]CH3OTf | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한방사성의약품학회지, v.3, no.1, pp.32 - 37 | - |
dc.identifier.kciid | ART002404711 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 37 | - |
dc.citation.startPage | 32 | - |
dc.citation.title | 대한방사성의약품학회지 | - |
dc.citation.volume | 3 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | 이상윤 | - |
dc.contributor.affiliatedAuthor | Tatsuo Ido | - |
dc.subject.keywordAuthor | 11C-sertraline | - |
dc.subject.keywordAuthor | PET | - |
dc.subject.keywordAuthor | [11C]CH3OTf | - |
dc.subject.keywordAuthor | Loop method | - |
dc.subject.keywordAuthor | SSRI | - |
dc.description.journalRegisteredClass | other | - |
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