Effect of acupuncture on memory function in old rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최인호 | - |
dc.contributor.author | 임형호 | - |
dc.date.available | 2020-02-27T21:42:51Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1010-0695 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7036 | - |
dc.description.abstract | Objectives: We investigated the effect of acupuncture on memory function in relation with neurogenesis in old rats. Methods: In this study, a step-down avoidance task for short-term memory and Y-maze task for spatial memory capability were conducted. Western blot analysis for brain-derived neurotorphic factor (BDNF) and tyrosine kinase B (TrkB), and immunohistochemistry for 5-bromo-2’-deoxyuridine (BrdU) were performed. Results: Short-term memory and spatial memories were decreased in the old-aged rats. Expressions of BDNF and TrkB in the hippocampus were significantly decreased in the old-aged rats. Neurogenesis in the hippocampal dentate gyrus was also decreased in the old-aged rats. However, acupuncture treatment alleviated impairment of short-term and spatial memories induced by ageing. Acupuncture also increased the expressions of BDNF and TrkB and enhanced neurogenesis in the hippocampus. The present study showed that acupuncture alleviated ageing-induced short-term and spatial memory loss by increasing of BDNF and neurogenesis. Acupuncture at ST41-acupoint showed most potent effect than at ST36-acupoint or non-acupoint. Conclusions: Acupuncture might be used as the effective therapeutic modality to ameliorate the age-related decrease of brain functions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한한의학회 | - |
dc.relation.isPartOf | 대한한의학회지 | - |
dc.title | Effect of acupuncture on memory function in old rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한한의학회지, v.38, no.2, pp.31 - 40 | - |
dc.identifier.kciid | ART002242620 | - |
dc.citation.endPage | 40 | - |
dc.citation.startPage | 31 | - |
dc.citation.title | 대한한의학회지 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | 최인호 | - |
dc.contributor.affiliatedAuthor | 임형호 | - |
dc.subject.keywordAuthor | Aging | - |
dc.subject.keywordAuthor | acupuncture | - |
dc.subject.keywordAuthor | neurogenesis | - |
dc.subject.keywordAuthor | brain-derived neurotorphic factor | - |
dc.subject.keywordAuthor | short-term memory | - |
dc.subject.keywordAuthor | spatial memory | - |
dc.description.journalRegisteredClass | kci | - |
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