Inductively Coupled RF Coil for Imaging a 40 µm-Thick Histology Sample in a Clinical MRI Scanner
DC Field | Value | Language |
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dc.contributor.author | Song Byung-Pan | - |
dc.contributor.author | Kim Hyeong-Seop | - |
dc.contributor.author | Kim Kyoung-Nam | - |
dc.contributor.author | Lee Seung-Kyun | - |
dc.date.available | 2020-07-30T00:35:39Z | - |
dc.date.created | 2020-07-15 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 0374-4884 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/71654 | - |
dc.description.abstract | A histology coil is a U-shaped radio-frequency (RF) coil that is designed to provide a high signal-to-noise ratio (SNR) in magnetic resonance imaging (MRI) of microscopically thin samples. In this work, we demonstrate an inductively coupled histology coil that can be easily integrated with a human MRI scanner, providing a simple method to conduct novel, microscopic imaging experiments in a clinical scanner. All experiments were conducted in a 3T whole-body MRI scanner. The coil consisted of a U-shaped copper foil with tuning capacitors shunting the ends of the “U”. This design maximizes the B1-field efficiency and the homogeneity in the coil's cavity. For inductive coupling, the histology coil was connected to an untuned single-turn pick-up loop via a coaxial cable. A standard 3T receive-only surface coil, connected to the scanner's standard receive circuitry, was then inductively coupled to the pick-up loop. Separately, the RF pulse transmitted from the MRI body coil inductively drove the histology coil. In gel phantom imaging, we confirmed a higher (threefold) SNR for the histology coil than for the scanner's standard surface coil, as well as high B1 homogeneity for the histology coil. Gradient echo images of a 40-μm-thick rat brain slice, at an in-plane resolution of 219 × 219 μm2, could be obtained with SNR > 10 (in the cortex) in about 2 hours. Our work demonstrates the feasibility of imaging microscopically thin tissue slices in a clinical MRI scanner using an inductively coupled histology coil. The method can be applied to multi-modality and multi-orientation imaging of ex-vivo and engineered tissue samples. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국물리학회 | - |
dc.relation.isPartOf | Journal of the Korean Physical Society | - |
dc.title | Inductively Coupled RF Coil for Imaging a 40 µm-Thick Histology Sample in a Clinical MRI Scanner | - |
dc.title.alternative | Inductively Coupled RF Coil for Imaging a 40 µm-Thick Histology Sample in a Clinical MRI Scanner | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000548539000014 | - |
dc.identifier.doi | 10.3938/jkps.77.87 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Physical Society, v.77, no.1, pp.87 - 93 | - |
dc.identifier.kciid | ART002608814 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85087926298 | - |
dc.citation.endPage | 93 | - |
dc.citation.startPage | 87 | - |
dc.citation.title | Journal of the Korean Physical Society | - |
dc.citation.volume | 77 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kim Kyoung-Nam | - |
dc.subject.keywordAuthor | MRI | - |
dc.subject.keywordAuthor | RF coil | - |
dc.subject.keywordAuthor | Inductive coupling | - |
dc.subject.keywordAuthor | Ex-vivo | - |
dc.subject.keywordAuthor | Histology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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