Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, D. | - |
dc.contributor.author | Hong, K.-T. | - |
dc.contributor.author | Lim, T.S. | - |
dc.contributor.author | Lee, E. | - |
dc.contributor.author | Lee, Y.H. | - |
dc.contributor.author | Park, J.S. | - |
dc.contributor.author | Kim, W. | - |
dc.contributor.author | Oh, J.H. | - |
dc.contributor.author | Choi, J.-A. | - |
dc.contributor.author | Song, Y. | - |
dc.date.available | 2020-07-30T00:35:45Z | - |
dc.date.created | 2020-07-13 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 1471-2474 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/71656 | - |
dc.description.abstract | BACKGROUND: The role of altered joint mechanics on cartilage degeneration in in vivo models has not been studied successfully due to a lack of pre-injury information. We aimed 1) to develop an accurate in vivo canine model to measure the changes in joint loading and T2 star (T2*) relaxation time before and after unilateral supraspinatus tendon resections, and 2) to find the relationship between regional variations in articular cartilage loading patterns and T2* relaxation time distributions. METHODS: Rigid markers were implanted in the scapula and humerus of tested dogs. The movement of the shoulder bones were measured by a motion tracking system during normal gaits. In vivo cartilage contact strain was measured by aligning 3D shoulder models with the motion tracking data. Articular cartilage T2* relaxation times were measured by quantitative MRI scans. Articular cartilage contact strain and T2* relaxation time were compared in the shoulders before and 3 months after the supraspinatus tendon resections. RESULTS: Excellent accuracy and reproducibility were found in our in vivo contact strain measurements with less than 1% errors. Changes in articular cartilage contact strain exhibited similar patterns with the changes in the T2* relaxation time after resection surgeries. Regional changes in the articular cartilage T2* relaxation time exhibited positive correlations with regional contact strain variations 3 months after the supraspinatus resection surgeries. CONCLUSION: This is the first study to measure in vivo articular cartilage contact strains with high accuracy and reproducibility. Positive correlations between contact strain and T2* relaxation time suggest that the articular cartilage extracellular matrix may responds to mechanical changes in local areas. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NLM (Medline) | - |
dc.relation.isPartOf | BMC musculoskeletal disorders | - |
dc.title | Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000548924800002 | - |
dc.identifier.doi | 10.1186/s12891-020-03447-3 | - |
dc.identifier.bibliographicCitation | BMC musculoskeletal disorders, v.21, no.1, pp.424 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85087474364 | - |
dc.citation.startPage | 424 | - |
dc.citation.title | BMC musculoskeletal disorders | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lim, T.S. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Animal model | - |
dc.subject.keywordAuthor | Articular cartilage | - |
dc.subject.keywordAuthor | Biomechanics | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Osteoarthritis | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.