Characterization of hepatitis B surface antigen loaded polylactic acid-based microneedle and its dermal safety profile
DC Field | Value | Language |
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dc.contributor.author | Na Y.-G. | - |
dc.contributor.author | Kim M. | - |
dc.contributor.author | Han M. | - |
dc.contributor.author | Huh H.W. | - |
dc.contributor.author | Kim J.-S. | - |
dc.contributor.author | Kim J.C. | - |
dc.contributor.author | Park J.-H. | - |
dc.contributor.author | Lee H.-K. | - |
dc.contributor.author | Cho C.-W. | - |
dc.date.available | 2020-07-30T05:35:21Z | - |
dc.date.created | 2020-06-15 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/71756 | - |
dc.description.abstract | A surge of interest in microneedle (MN) vaccines as a novel vaccination system has emerged. Before the clinical application of MN vaccine, an assessment of potential biological risks to skin and quality control of MN must be performed. Therefore, the present study aims to evaluate the physicochemical properties of MN and to evaluate the histological changes and inflammatory cell infiltrations after the application of MN with hepatitis B surface antigen (HBsAg). During in vitro and in vivo release testing, HBsAg MN released over 70% of HBsAg at 30 min. During the pyrogen test of HBsAg MN in rabbit, no rabbit showed an individual rise in temperature of 0.5◦ C or more. MN with HBsAg produced the moderate immunization in mice. MN application did not alter the thickness of dermal and epidermal layers in mice. In addition, the topical applications of MN and MN for hepatitis B vaccine did not acutely induce the inflammation, allergic reaction, dermal toxicity and skin irritation. Thus, the MN system for the delivery of HBsAg could be the promising technology in the hepatitis B vaccination. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Pharmaceutics | - |
dc.title | Characterization of hepatitis B surface antigen loaded polylactic acid-based microneedle and its dermal safety profile | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000551195100001 | - |
dc.identifier.doi | 10.3390/pharmaceutics12060531 | - |
dc.identifier.bibliographicCitation | Pharmaceutics, v.12, no.6, pp.1 - 14 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85086134524 | - |
dc.citation.endPage | 14 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Pharmaceutics | - |
dc.citation.volume | 12 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Kim J.-S. | - |
dc.contributor.affiliatedAuthor | Kim J.C. | - |
dc.contributor.affiliatedAuthor | Park J.-H. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Acute dermal toxicity | - |
dc.subject.keywordAuthor | Dermal safety | - |
dc.subject.keywordAuthor | Hepatitis B vaccine | - |
dc.subject.keywordAuthor | Microneedle | - |
dc.subject.keywordAuthor | Polylactic acid | - |
dc.subject.keywordAuthor | Skin irritation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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