Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential
DC Field | Value | Language |
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dc.contributor.author | Lee, Yeon Kyung | - |
dc.contributor.author | Kim, Sang-Woo | - |
dc.contributor.author | Park, Jun-Young | - |
dc.contributor.author | Kang, Woong Chol | - |
dc.contributor.author | Kang, Youn Joo | - |
dc.contributor.author | Khang, Dongwoo | - |
dc.date.available | 2020-02-27T23:41:39Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7476 | - |
dc.description.abstract | Dexamethasone (DEX), a non-particulate glucocorticoid (GC) to inhibit anti-inflammatory response, has been widely used for the treatment of various diseases such as arthritis, cancer, asthma, chronic obstructive pulmonary disease, cerebral edema, and multiple sclerosis. However, prolonged and/or high-dose GC therapy can cause various serious adverse effects (adrenal insufficiency, hyperglycemia, Cushing's syndrome, osteoporosis, Charcot arthropathy, etc). In this study, developed DEX-carbon nanotube (CNT) conjugates improved intracellular drug delivery via increased caveolin-dependent endocytosis and ultimately suppressed the expression of major pro-inflammatory cytokines in tumor necrosis factor-alpha (TNF-alpha)stimulated human fibroblast-like synoviocytes (FLS) at low drug concentrations. Specifically, DEX on polyethylene-glycol (PEG)-coated CNTs induced caveolin uptake, recovered mitochondrial disruption, and inhibited reactive oxygen species production by targeting mitochondria that was released from the early endosome in TNF-alpha-stimulated FLS. The obtained results clearly demonstrated that DEX-PEG-coated CNTs significantly inhibited the inflammation by FLS in rheumatoid arthritis (RA) by achieving greater drug uptake and efficient intracellular drug release from the endosome, thus suggesting a mechanism of effective low-dose GC therapy to treat inflammatory diseases, including RA and osteoarthritis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.title | Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000407585200002 | - |
dc.identifier.doi | 10.2147/IJN.S142122 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.12, pp.5761 - 5778 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85027364305 | - |
dc.citation.endPage | 5778 | - |
dc.citation.startPage | 5761 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Lee, Yeon Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Sang-Woo | - |
dc.contributor.affiliatedAuthor | Park, Jun-Young | - |
dc.contributor.affiliatedAuthor | Kang, Woong Chol | - |
dc.contributor.affiliatedAuthor | Kang, Youn Joo | - |
dc.contributor.affiliatedAuthor | Khang, Dongwoo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | carbon nanotubes | - |
dc.subject.keywordAuthor | polyethylene-glycol | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | arthritis | - |
dc.subject.keywordAuthor | fibroblast-like synoviocytes | - |
dc.subject.keywordAuthor | caveolin-dependent endocytosis | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | THERAPEUTIC IMPLICATIONS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | TNF | - |
dc.subject.keywordPlus | OSTEOARTHRITIS | - |
dc.subject.keywordPlus | NANOMEDICINES | - |
dc.subject.keywordPlus | SYNOVIOCYTES | - |
dc.subject.keywordPlus | NANOPARTICLE | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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