Naphthoquinones from Handroanthus impetiginosus promote skin wound healing through Sirt3 regulation
DC Field | Value | Language |
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dc.contributor.author | Ahmad, Fayyaz | - |
dc.contributor.author | Bibi, Shaheen | - |
dc.contributor.author | Kang, Mincheol | - |
dc.contributor.author | Anees, Mariam | - |
dc.contributor.author | Ansar, Muhammad | - |
dc.contributor.author | Alam, Muhammad Rizwan | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Wahedi, Hussain Mustatab | - |
dc.date.available | 2020-08-10T06:35:17Z | - |
dc.date.created | 2020-08-10 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2008-3866 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/76299 | - |
dc.description.abstract | Objective(s): Lapachone is a natural naphthoquinone-derived compound found in Tabebuia avellanedae. It is well-known for its analgesic, anti-inflammatory, anti -microbial, diuretic, and anti cancerous effects. However, the wound-healing effects of this compound are not known yet. The aim of this study was to investigate the wound healing activity of naphthoquinones (alpha-lapachone and beta-lapachone) from Handroanthus impetiginosus. Materials and Methods: Expression of Sirt3, migration-related proteins (Racl, Cdc42, alpha-Pak) and angiogenesis-related protein of vascular endothelial growth factor (VEGF) was monitored using western blot analysis. Blood vessel formation and tissue development were monitored by angiogenesis assay and hematoxylin & eosin (H & E) staining, respectively on mouse skin tissue samples. Both alpha-lapachone and beta-lapachone increased Sirt3 expression in vivo, but only beta-lapachone increased Sirt3 expression in vitro. Results: Both the compounds accelerated wound healing in cultured skin cells as well as mouse skin; however, beta-lapachone was more effective at lower concentrations. Both of the compounds increased the expression of migration -related proteins both in vitro and in vivo. Similarly, alpha-lapachone and beta-lapachone increased VEGF expression, tissue development and blood vessel formation in mouse skin. Conclusion: These findings indicated that alpha-lapachone and beta-lapachone are novel Sirt3 activators, and Sirt3 has a role in wound healing. Thus, Sirt3 and its regulators come out as a novel target and potential drug candidates, respectively in the important field of cutaneous wound healing. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | University of Medical Sciences | - |
dc.relation.isPartOf | Iranian Journal of Basic Medical Sciences | - |
dc.title | Naphthoquinones from Handroanthus impetiginosus promote skin wound healing through Sirt3 regulation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000552750700005 | - |
dc.identifier.doi | 10.22038/ijbms.2020.43706.10275 | - |
dc.identifier.bibliographicCitation | Iranian Journal of Basic Medical Sciences, v.23, no.9, pp.1139 - 1145 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85090246646 | - |
dc.citation.endPage | 1145 | - |
dc.citation.startPage | 1139 | - |
dc.citation.title | Iranian Journal of Basic Medical Sciences | - |
dc.citation.volume | 23 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Kang, Mincheol | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Beta-Lapachone | - |
dc.subject.keywordAuthor | Dermatology | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Regeneration | - |
dc.subject.keywordAuthor | Tabebuia | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CELL-MIGRATION | - |
dc.subject.keywordPlus | JUGLONE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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