Cyanidin 3-O-glucoside Isolated from Lonicera caerulea Fruit Improves Glucose Response in INS-1 Cells by Improving Insulin Secretion and Signaling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Ham, Jungyeob | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Lee, Hae-Jeung | - |
dc.date.available | 2020-02-27T23:43:55Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7636 | - |
dc.description.abstract | Cyaniding 3-O-glucoside is a flavonoid compound isolated from the fruits of the Lonicera caerulea. In the present study, we investigated the effects of L. caerulea extract and its active component cyaniding 3-O-glucoside on insulin release in INS-1 cells. L. caerulea extract and cyanidin 3-O-glucoside activated the secretion of insulin that lead to diminished glucose production in INS-1 cells. Cyanidin 3-O-glucoside also enhanced the phosphorylation of insulin receptor, insulin receptor substrate 1, and phosphoinositide 3-kinase protein expressions in INS-1 cells. These results suggest that cyanidin 3-O-glucoside is an active component of L. caerulea that enhances insulin production and activates insulin signaling. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.subject | PANCREATIC BETA-CELLS | - |
dc.subject | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject | IN-VITRO | - |
dc.subject | RESISTANCE | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | MICE | - |
dc.subject | ANTHOCYANIN | - |
dc.subject | APOPTOSIS | - |
dc.subject | GINSENG | - |
dc.subject | DAMAGE | - |
dc.title | Cyanidin 3-O-glucoside Isolated from Lonicera caerulea Fruit Improves Glucose Response in INS-1 Cells by Improving Insulin Secretion and Signaling | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000390270200020 | - |
dc.identifier.doi | 10.1002/bkcs.11017 | - |
dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.12, pp.2015 - 2018 | - |
dc.identifier.kciid | ART002172606 | - |
dc.identifier.scopusid | 2-s2.0-85003451586 | - |
dc.citation.endPage | 2018 | - |
dc.citation.startPage | 2015 | - |
dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.volume | 37 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.contributor.affiliatedAuthor | Lee, Hae-Jeung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cyanidin 3-O-glucoside | - |
dc.subject.keywordAuthor | Glucose response | - |
dc.subject.keywordAuthor | Insulin secretion | - |
dc.subject.keywordAuthor | Lonicera caerulea | - |
dc.subject.keywordPlus | PANCREATIC BETA-CELLS | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ANTHOCYANIN | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | GINSENG | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.