Cyanidin 3-O-glucoside Isolated from Lonicera caerulea Fruit Improves Glucose Response in INS-1 Cells by Improving Insulin Secretion and Signaling

Abstract

Cyaniding 3-O-glucoside is a flavonoid compound isolated from the fruits of the Lonicera caerulea. In the present study, we investigated the effects of L. caerulea extract and its active component cyaniding 3-O-glucoside on insulin release in INS-1 cells. L. caerulea extract and cyanidin 3-O-glucoside activated the secretion of insulin that lead to diminished glucose production in INS-1 cells. Cyanidin 3-O-glucoside also enhanced the phosphorylation of insulin receptor, insulin receptor substrate 1, and phosphoinositide 3-kinase protein expressions in INS-1 cells. These results suggest that cyanidin 3-O-glucoside is an active component of L. caerulea that enhances insulin production and activates insulin signaling.