Thyroid-stimulating hormone improves insulin sensitivity in skeletal muscle cells via cAMP/PKA/CREB pathway-dependent upregulation of insulin receptor substrate-1 expression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Min Kyong | - |
dc.contributor.author | Kang, Geun Hyung | - |
dc.contributor.author | Kim, Hwan Hee | - |
dc.contributor.author | Han, Sun Kyoung | - |
dc.contributor.author | Do Koo, Young | - |
dc.contributor.author | Cho, Sun Wook | - |
dc.contributor.author | Kim, Ye An | - |
dc.contributor.author | Oh, Byung-Chul | - |
dc.contributor.author | Park, Do Joon | - |
dc.contributor.author | Chung, Sung Soo | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Park, Young Joo | - |
dc.date.available | 2020-02-27T23:44:34Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-11-15 | - |
dc.identifier.issn | 0303-7207 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7686 | - |
dc.description.abstract | Thyroid-stimulating hormone (TSH) receptor is expressed in extrathyroidal tissues such as hepatocytes, adipocytes, and skeletal muscle, which suggests a possible novel role of TSH in various metabolic processes in extrathyroidal tissues independent of thyroid hormones. We investigated whether TSH has any effects on glucose tolerance and insulin sensitivity in the skeletal muscle using diet-induced obesity (DIO) mouse models and rodent skeletal muscle cells. TSH improved glucose tolerance in DIO mice and this was associated with an improvement of skeletal muscle insulin sensitivity resulting from the increased expression of insulin receptor substrate (IRS)-1 protein and mRNA therein. TSH significantly increased both basal and insulin-stimulated glucose transport in rat L6 myotubes and increased the expression of IRS-1 protein and mRNA in these cells as well. TSH also stimulated Irs1 promoter activation; this stimulation was abolished by protein kinase A (PICA) inhibition using H89 or by mutation of the cAMP-response element site located at -1155 to -875 bp of the Irs1 promoter region, supporting a novel role of TSH activated-cAMP/PKA/CREB signaling in the regulation of Irs1 expression. In conclusion, TSH improves insulin sensitivity in skeletal muscle by increasing Irs1 gene expression. This regulatory effect is mediated by a PKA-CREB-dependent pathway. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR ENDOCRINOLOGY | - |
dc.subject | TSH RECEPTOR | - |
dc.subject | THYROTROPIN RECEPTOR | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | RESISTANCE | - |
dc.subject | HYPOTHYROIDISM | - |
dc.subject | POLYMORPHISM | - |
dc.subject | METABOLISM | - |
dc.subject | GLUCOSE | - |
dc.subject | DYSFUNCTION | - |
dc.subject | HUMANS | - |
dc.title | Thyroid-stimulating hormone improves insulin sensitivity in skeletal muscle cells via cAMP/PKA/CREB pathway-dependent upregulation of insulin receptor substrate-1 expression | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000403629800006 | - |
dc.identifier.doi | 10.1016/j.mce.2016.07.018 | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR ENDOCRINOLOGY, v.436, no.C, pp.50 - 58 | - |
dc.identifier.scopusid | 2-s2.0-84979590739 | - |
dc.citation.endPage | 58 | - |
dc.citation.startPage | 50 | - |
dc.citation.title | MOLECULAR AND CELLULAR ENDOCRINOLOGY | - |
dc.citation.volume | 436 | - |
dc.citation.number | C | - |
dc.contributor.affiliatedAuthor | Oh, Byung-Chul | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Thyroid-stimulating hormone | - |
dc.subject.keywordAuthor | Insulin sensitivity | - |
dc.subject.keywordAuthor | Skeletal muscle | - |
dc.subject.keywordAuthor | Insulin receptor substrate-1 | - |
dc.subject.keywordPlus | TSH RECEPTOR | - |
dc.subject.keywordPlus | THYROTROPIN RECEPTOR | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | HYPOTHYROIDISM | - |
dc.subject.keywordPlus | POLYMORPHISM | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | HUMANS | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.