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ROS homeostasis and metabolism: a critical liaison for cancer therapy

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dc.contributor.authorKim, Jongdoo-
dc.contributor.authorKim, Jaehong-
dc.contributor.authorBae, Jong-Sup-
dc.date.available2020-02-27T23:44:57Z-
dc.date.created2020-02-07-
dc.date.issued2016-11-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7716-
dc.description.abstractEvidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can also alter the redox balance. Thus, important steps toward developing novel cancer therapy approaches would be to identify and modulate critical biochemical nodes that are deregulated in cancer metabolism and determine if the therapeutic efficiency can be influenced by changes in redox homeostasis in cancer tissues. In this review, we will explore the molecular mechanisms responsible for the metabolic reprogramming of tumor microenvironments, the functional modulation of which may disrupt the effects of or may be disrupted by redox homeostasis modulating cancer therapy.-
dc.language영어-
dc.language.isoen-
dc.publisherNATURE PUBLISHING GROUP-
dc.relation.isPartOfEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.subjectPYRUVATE-DEHYDROGENASE KINASE-
dc.subjectINDUCIBLE FACTOR-I-
dc.subjectMITOCHONDRIAL OXIDATIVE-METABOLISM-
dc.subjectPROTEIN-TYROSINE KINASES-
dc.subjectSMOOTH-MUSCLE-CELLS-
dc.subjectNF-KAPPA-B-
dc.subjectLACTATE-DEHYDROGENASE-
dc.subjectREDOX REGULATION-
dc.subjectBREAST-CANCER-
dc.subject6-PHOSPHOFRUCTO-2-KINASE PFKFB3-
dc.titleROS homeostasis and metabolism: a critical liaison for cancer therapy-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000391820400003-
dc.identifier.doi10.1038/emm.2016.119-
dc.identifier.bibliographicCitationEXPERIMENTAL AND MOLECULAR MEDICINE, v.48-
dc.identifier.kciidART002165831-
dc.identifier.scopusid2-s2.0-84994608607-
dc.citation.titleEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.citation.volume48-
dc.contributor.affiliatedAuthorKim, Jongdoo-
dc.contributor.affiliatedAuthorKim, Jaehong-
dc.type.docTypeReview-
dc.subject.keywordPlusPYRUVATE-DEHYDROGENASE KINASE-
dc.subject.keywordPlusINDUCIBLE FACTOR-I-
dc.subject.keywordPlusMITOCHONDRIAL OXIDATIVE-METABOLISM-
dc.subject.keywordPlusPROTEIN-TYROSINE KINASES-
dc.subject.keywordPlusSMOOTH-MUSCLE-CELLS-
dc.subject.keywordPlusNF-KAPPA-B-
dc.subject.keywordPlusLACTATE-DEHYDROGENASE-
dc.subject.keywordPlusREDOX REGULATION-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlus6-PHOSPHOFRUCTO-2-KINASE PFKFB3-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
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