Andrographis paniculata extract relieves pain and inflammation in monosodium iodoacetate-induced osteoarthritis and acetic acid-inducedwrithing in animal models
DC Field | Value | Language |
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dc.contributor.author | Lee, D. | - |
dc.contributor.author | Baek, C.Y. | - |
dc.contributor.author | Hwang, J.H. | - |
dc.contributor.author | Kim, M.-Y. | - |
dc.date.available | 2020-08-13T01:35:41Z | - |
dc.date.created | 2020-08-10 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 2227-9717 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/77452 | - |
dc.description.abstract | Osteoarthritis (OA), being the most prominent degenerative joint disease is affecting millions of elderly people worldwide. Although Andrographis paniculata is an ethnic medicine with a long history of being used as analgesic agent, no study using a monosodium iodoacetate (MIA) model has investigated its potential activities against OA. In this study, experimental OA was induced in rats with a knee injection of MIA, which represents the pathological characteristics of OA in humans. A. paniculata extract (APE) substantially reversed the loss of hind limb weight-bearing and the cartilage damage resulted from the OA induction in rats. Additionally, the levels of serum pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α as well as the concentration of matrix metalloproteinases, including MMP-1, MMP-3, MMP-8, and MMP-13 were decreased by APE administration. Acetic acid-induced writhing responses in mice which quantitatively measure pain were significantly reduced by APE. In vitro, APE inhibited the generation of NO and downregulated the expression of IL-1β, IL-6, COX-2, and iNOS in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The above results suggest the potential use APE as a therapeutic agent against OA. © 2020 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Processes | - |
dc.title | Andrographis paniculata extract relieves pain and inflammation in monosodium iodoacetate-induced osteoarthritis and acetic acid-inducedwrithing in animal models | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000554273700001 | - |
dc.identifier.doi | 10.3390/pr8070873 | - |
dc.identifier.bibliographicCitation | Processes, v.8, no.7 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85088598423 | - |
dc.citation.title | Processes | - |
dc.citation.volume | 8 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Lee, D. | - |
dc.contributor.affiliatedAuthor | Baek, C.Y. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Analgesic | - |
dc.subject.keywordAuthor | Andrographis paniculata | - |
dc.subject.keywordAuthor | Anti-inflammatory | - |
dc.subject.keywordAuthor | Osteoarthritis | - |
dc.subject.keywordAuthor | Pain | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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