Effect of quamoclit angulata extract supplementation on oxidative stress and inflammation on hyperglycemia-induced renal damage in type 2 diabetic mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park J.E. | - |
dc.contributor.author | Lee H. | - |
dc.contributor.author | Rho H. | - |
dc.contributor.author | Hong S.M. | - |
dc.contributor.author | Kim S.Y. | - |
dc.contributor.author | Lim Y. | - |
dc.date.available | 2020-08-13T01:35:56Z | - |
dc.date.created | 2020-06-12 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/77459 | - |
dc.description.abstract | Type 2 diabetes mellitus (T2DM) is caused by abnormalities of controlling blood glucose and insulin homeostasis. Especially, hyperglycemia causes hyper-inflammation through activation of NLRP3 inflammasome, which can lead to cell apoptosis, hypertrophy, and fibrosis. Quamoclit angulata (QA), one of the annual winders, has been shown ameliorative effects on diabetes. The current study investigated whether the QA extract (QAE) attenuated hyperglycemia-induced renal inflammation related to NLRP inflammasome and oxidative stress in high fat diet (HFD)-induced diabetic mice. After T2DM was induced, the mice were treated with QAE (5 or 10 mg/kg/day) by gavage for 12 weeks. The QAE supplementation reduced homeostasis model assessment insulin resistance (HOMA-IR), kidney malfunction, and glomerular hypertrophy in T2DM. Moreover, the QAE treatment significantly attenuated renal NLRP3 inflammasome dependent hyperinflammation and consequential renal damage caused by oxidative stress, apoptosis, andfibrosis in T2DM. Furthermore, QAE normalized aberrant energy metabolism (downregulation of p-AMPK, sirtuin (SIRT)-1, and PPARγ-coactivator α (PGC-1 α)) in T2DM mice. Taken together, the results suggested that QAE as a natural product has ameliorative effects on renal damage by regulationof oxidative stress and inflammation in T2DM. © 2020 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Antioxidants | - |
dc.title | Effect of quamoclit angulata extract supplementation on oxidative stress and inflammation on hyperglycemia-induced renal damage in type 2 diabetic mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000553512400001 | - |
dc.identifier.doi | 10.3390/antiox9060459 | - |
dc.identifier.bibliographicCitation | Antioxidants, v.9, no.6 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85085875403 | - |
dc.citation.title | Antioxidants | - |
dc.citation.volume | 9 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Hong S.M. | - |
dc.contributor.affiliatedAuthor | Kim S.Y. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Fibrosis | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Kidney damage | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Quamoclit angulata | - |
dc.subject.keywordAuthor | Type 2 diabetes | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.