Differential pulse voltammetric electrochemical sensor for the detection of etidronic acid in pharmaceutical samples by using rgo-ag@sio2/au pcb
- Authors
- Selvam, S.P.; Chinnadayyala, S.R.; Cho, S.; Yun, K.
- Issue Date
- Jul-2020
- Publisher
- MDPI AG
- Keywords
- Differential pulse voltammetry; Etidronic acid; Self-assembly; Ultrasonic irradiation
- Citation
- Nanomaterials, v.10, no.7, pp.1 - 17
- Journal Title
- Nanomaterials
- Volume
- 10
- Number
- 7
- Start Page
- 1
- End Page
- 17
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/77550
- DOI
- 10.3390/nano10071368
- ISSN
- 2079-4991
- Abstract
- An rGO-Ag@SiO2 nanocomposite-based electrochemical sensor was developed to detect etidronic acid (EA) using the differential pulse voltammetric (DPV) technique. Rapid self-assembly of the rGO-Ag@SiO2 nanocomposite was accomplished through probe sonication. The developed rGO-Ag@SiO2 nanocomposite was used as an electrochemical sensing platform by drop-casting on a gold (Au) printed circuit board (PCB). Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) confirmed the enhanced electrochemical active surface area (ECASA) and low charge transfer resistance (Rct ) of the rGO-Ag@SiO2 /Au PCB. The accelerated electron transfer and the high number of active sites on the rGO-Ag@SiO2/Au PCB resulted in the electrochemical detection of EA through the DPV technique with a limit of detection (LOD) of 0.68 µM and a linear range of 2.0–200.0 µM. The constructed DPV sensor exhibited high selectivity toward EA, high reproducibility in terms of different Au PCBs, excellent repeatability, and long-term stability in storage at room temperature (25◦C). The real-time application of the rGO-Ag@SiO2/Au PCB for EA detection was investigated using EA-based pharmaceutical samples. Recovery percentages between 96.2% and 102.9% were obtained. The developed DPV sensor based on an rGO-Ag@SiO2 /Au PCB could be used to detect other electrochemically active species following optimization under certain conditions. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
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