Five New Pregnane Glycosides from Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities
DC Field | Value | Language |
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dc.contributor.author | Kiem P.V. | - |
dc.contributor.author | Yen D.T.H. | - |
dc.contributor.author | Hung N.V. | - |
dc.contributor.author | Nhiem N.X. | - |
dc.contributor.author | Tai B.H. | - |
dc.contributor.author | Trang D.T. | - |
dc.contributor.author | Yen P.H. | - |
dc.contributor.author | Ngoc T.M. | - |
dc.contributor.author | Minh C.V. | - |
dc.contributor.author | Park S. | - |
dc.contributor.author | Lee J.H. | - |
dc.contributor.author | Kim S.Y. | - |
dc.contributor.author | Kim S.H. | - |
dc.date.available | 2020-08-13T06:35:42Z | - |
dc.date.created | 2020-06-08 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/77555 | - |
dc.description.abstract | Gymnema sylvestre, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation of Gymnema sylvestre led to the isolation of five new pregnane glycosides, gymsylosides A-E (1-5) and four known oleanane saponins, 3β-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (6), gymnemoside-W1 (7), 3β-O-β-D-xylopyranosyl-(1→6)-β-D- glucopyranosyl-(1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (8), and alternoside XIX (9). Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for their α-glucosidase and α-amylase inhibitory activities. Compounds 2-4 showed significant α-amylase inhibitory activity, with IC50 values ranging from 113.0 to 176.2 µM. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Molecules (Basel, Switzerland) | - |
dc.title | Five New Pregnane Glycosides from Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000553858800062 | - |
dc.identifier.doi | 10.3390/molecules25112525 | - |
dc.identifier.bibliographicCitation | Molecules (Basel, Switzerland), v.25, no.11 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85085677655 | - |
dc.citation.title | Molecules (Basel, Switzerland) | - |
dc.citation.volume | 25 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Lee J.H. | - |
dc.contributor.affiliatedAuthor | Kim S.Y. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Asclepiadacaea | - |
dc.subject.keywordAuthor | Gymnema sylvestre | - |
dc.subject.keywordAuthor | gymsyloside | - |
dc.subject.keywordAuthor | pregnane | - |
dc.subject.keywordAuthor | α-amylase | - |
dc.subject.keywordAuthor | α-glucosidase | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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