Body Mass Index with Tumor F-18-FDG Uptake Improves Risk Stratification in Patients with Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | Hyun, Seung Hyup | - |
dc.contributor.author | Ahn, Hee Kyung | - |
dc.contributor.author | Lee, Joo Hee | - |
dc.contributor.author | Choi, Joon Young | - |
dc.contributor.author | Kim, Byung-Tae | - |
dc.contributor.author | Park, Yeon Hee | - |
dc.contributor.author | Im, Young-Hyuck | - |
dc.contributor.author | Lee, Jeong Eon | - |
dc.contributor.author | Nam, Seok Jin | - |
dc.contributor.author | Lee, Kyung-Han | - |
dc.date.available | 2020-02-28T00:42:09Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-10-31 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7778 | - |
dc.description.abstract | Purpose To investigate the combined prognostic impact of body mass index (BMI) and tumor standardized uptake value (SUV) measured on pretreatment 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in patients with breast cancer. Methods We evaluated a cohort of 332 patients with newly diagnosed breast cancer (stage I-III) who underwent pretreatment FDG PET/CT followed by curative resection. Patients were categorized as overweight (BMI >= 23 kg/m(2)) or normal weight (BMI < 23 kg/m(2)). Primary tumor maximum SUV was measured by FDG PET/CT. Associations between BMI and tumor SUV with disease recurrence were assessed using Cox regression models. Results Median follow-up was 39 months. There were 76 recurrences and 15 cancer-related deaths. Multivariable Cox regression analysis demonstrated that high tumor SUV (hazard ratio [HR] = 1.75; 95% CI, 1.02-3.02; P = 0.044) and overweight (HR = 1.84; 95% CI, 1.17-2.89; P = 0.008) were independent poor prognostic factors. Positive hormone receptor status was an independent predictor of favorable outcome (HR = 0.42; 95% CI, 0.26-0.68; P < 0.001). Overweight patients with high tumor SUV had a two-fold risk of recurrence compared to patients with normal weight or low tumor SUV after adjusting for clinical stage and tumor subtype (HR = 2.06; 95% CI, 1.30-3.27; P = 0.002). Conclusions In patients with breast cancer, higher tumor SUV was associated with a more adverse outcome particularly in overweight women. BMI status combined with tumor SUV data allows better risk-stratification of breast cancer, independent of clinical stage and tumor subtype. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.subject | ESTROGEN-RECEPTOR | - |
dc.subject | POOLED ANALYSIS | - |
dc.subject | OBESITY | - |
dc.subject | WOMEN | - |
dc.subject | SURVIVAL | - |
dc.subject | SUBTYPES | - |
dc.subject | OUTCOMES | - |
dc.subject | INSULIN | - |
dc.subject | PREMENOPAUSAL | - |
dc.subject | CHEMOTHERAPY | - |
dc.title | Body Mass Index with Tumor F-18-FDG Uptake Improves Risk Stratification in Patients with Breast Cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000386711100069 | - |
dc.identifier.doi | 10.1371/journal.pone.0165814 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.11, no.10 | - |
dc.identifier.scopusid | 2-s2.0-84993929556 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Ahn, Hee Kyung | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR | - |
dc.subject.keywordPlus | POOLED ANALYSIS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | SUBTYPES | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | PREMENOPAUSAL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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