High-precision low-power DNA readout interface chip for multichannel nanopore applications
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jungsuk | - |
dc.contributor.author | Dunbarr, William B. | - |
dc.date.available | 2020-02-28T00:42:10Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-10-29 | - |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7780 | - |
dc.description.abstract | This paper presents a high-precision and low-power DNA readout interface chip (RIC) for multichannel nanopore applications. A current-to-voltage (I/V) converter, comprising a resistive-feedback transimpedance amplifier (rf-TIA) and a difference amplifier (diff-amp), is typically used as a DNA RIC to detect minute ionic currents through a nanopore channel. However, conventional rf-TIAs require an output buffer to drive a low resistive load raised from the diff-amp, which results in high power consumption and low area efficiency on a given chip size. This diff-amp also amplifies unwanted input offset voltage, which limits output dynamics. In this work, we replace the diff-amp with a non-inverting structure to avoid the need for an output buffer, and propose a novel offset cancellation block (OCB) to drastically reduce the deleterious offset effect. This DNA RIC is fabricated in a 0.35 mu m CMOS process and is demonstrated employing an alpha-hemolysin (alpha-HL) protein nanopore and 40-mer single-stranded DNA (ssDNA) molecules. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE SA | - |
dc.relation.isPartOf | SENSORS AND ACTUATORS B-CHEMICAL | - |
dc.subject | POTENTIOSTAT | - |
dc.subject | NOISE | - |
dc.title | High-precision low-power DNA readout interface chip for multichannel nanopore applications | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000378538700034 | - |
dc.identifier.doi | 10.1016/j.snb.2016.04.032 | - |
dc.identifier.bibliographicCitation | SENSORS AND ACTUATORS B-CHEMICAL, v.234, pp.273 - 277 | - |
dc.identifier.scopusid | 2-s2.0-84966389011 | - |
dc.citation.endPage | 277 | - |
dc.citation.startPage | 273 | - |
dc.citation.title | SENSORS AND ACTUATORS B-CHEMICAL | - |
dc.citation.volume | 234 | - |
dc.contributor.affiliatedAuthor | Kim, Jungsuk | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Multichannel nanopore | - |
dc.subject.keywordAuthor | alpha-Hemolysin | - |
dc.subject.keywordAuthor | Lab-on-a-chip | - |
dc.subject.keywordAuthor | DNA readout | - |
dc.subject.keywordAuthor | Low noise | - |
dc.subject.keywordAuthor | Single-molecule science | - |
dc.subject.keywordAuthor | High throughput DNA analysis | - |
dc.subject.keywordPlus | POTENTIOSTAT | - |
dc.subject.keywordPlus | NOISE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Electrochemistry | - |
dc.relation.journalResearchArea | Instruments & Instrumentation | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Electrochemistry | - |
dc.relation.journalWebOfScienceCategory | Instruments & Instrumentation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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