Signaling modulations of mir-206-3p in tooth morphogenesis
DC Field | Value | Language |
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dc.contributor.author | Neupane, S. | - |
dc.contributor.author | Aryal, Y.P. | - |
dc.contributor.author | Kim, T.-Y. | - |
dc.contributor.author | Yeon, C.-Y. | - |
dc.contributor.author | An, C.-H. | - |
dc.contributor.author | Kim, J.-Y. | - |
dc.contributor.author | Yamamoto, H. | - |
dc.contributor.author | Lee, Y. | - |
dc.contributor.author | Sohn, W.-J. | - |
dc.contributor.author | Kim, J.-Y. | - |
dc.date.available | 2020-08-27T05:35:38Z | - |
dc.date.created | 2020-08-10 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78050 | - |
dc.description.abstract | MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs that post-transcriptionally regulate gene expression in organisms. Most mammalian miRNAs influence biological processes, including developmental changes, tissue morphogenesis and the maintenance of tissue identity, cell growth, differentiation, apoptosis, and metabolism. The miR-206-3p has been correlated with cancer; however, developmental roles of this miRNA are unclear. In this study, we examined the expression pattern and evaluated the developmental regulation of miR-206-3p during tooth morphogenesis using ex-vivo culture method. The expression pattern of miR-206-3p was examined in the epithelium and mesenchyme of developing tooth germ with stage-specific manners. Perturbation of the expression of miR-206-3p clearly altered expression patterns of dental-development–related signaling molecules, including Axin2, Bmp2, Fgf4, Lef1 and Shh. The gene expression complemented with change in cellular events including, apoptosis and proliferation which caused altered crown and pulp morphogenesis in renal-capsule–calcified teeth. Especially, mislocalization of β-Catenin and SMAD1/5/8 were observed alongside dramatic alterations in the expression patterns of Fgf4 and Shh. Overall, our data suggest that the miR-206-3p regulate the cellular physiology during tooth morphogenesis through modulation of the Wnt, Bmp, Fgf, and Shh signaling pathways to form proper tooth pulp and crown. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | International Journal of Molecular Sciences | - |
dc.title | Signaling modulations of mir-206-3p in tooth morphogenesis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000559251100001 | - |
dc.identifier.doi | 10.3390/ijms21155251 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.21, no.15, pp.1 - 15 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85088811666 | - |
dc.citation.endPage | 15 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 21 | - |
dc.citation.number | 15 | - |
dc.contributor.affiliatedAuthor | Kim, J.-Y. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Epigenetic regulation | - |
dc.subject.keywordAuthor | Epithelial-mesenchymal interactions | - |
dc.subject.keywordAuthor | Signaling regulations | - |
dc.subject.keywordAuthor | Tooth crown formation | - |
dc.subject.keywordPlus | axin | - |
dc.subject.keywordPlus | axin2 | - |
dc.subject.keywordPlus | beta catenin | - |
dc.subject.keywordPlus | bone morphogenetic protein 2 | - |
dc.subject.keywordPlus | fibroblast growth factor 4 | - |
dc.subject.keywordPlus | lymphoid enhancer factor 1 | - |
dc.subject.keywordPlus | microRNA | - |
dc.subject.keywordPlus | microRNA 206 3p | - |
dc.subject.keywordPlus | peptides and proteins | - |
dc.subject.keywordPlus | Smad1 protein | - |
dc.subject.keywordPlus | Smad5 protein | - |
dc.subject.keywordPlus | Smad8 protein | - |
dc.subject.keywordPlus | sonic hedgehog protein | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | cell function | - |
dc.subject.keywordPlus | cell proliferation | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | embryo | - |
dc.subject.keywordPlus | epigenetics | - |
dc.subject.keywordPlus | epithelial mesenchymal transition | - |
dc.subject.keywordPlus | histology | - |
dc.subject.keywordPlus | immunohistochemistry | - |
dc.subject.keywordPlus | in situ hybridization | - |
dc.subject.keywordPlus | morphogenesis | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | pulp morphogenesis | - |
dc.subject.keywordPlus | real time polymerase chain reaction | - |
dc.subject.keywordPlus | shh signaling | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | tooth crown formation | - |
dc.subject.keywordPlus | tooth development | - |
dc.subject.keywordPlus | TUNEL assay | - |
dc.subject.keywordPlus | Wnt signaling | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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