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Evaluation of the Single-Dose Toxicity of Capsaicin Containing Pharmacopuncture in RatsEvaluation of the Single-Dose Toxicity of Capsaicin Containing Pharmacopuncture in Rats

Other Titles
Evaluation of the Single-Dose Toxicity of Capsaicin Containing Pharmacopuncture in Rats
Authors
황지혜구자승Chul Jung
Issue Date
Aug-2020
Publisher
대한침구의학회
Keywords
acupuncture; capsaicin; pharmacopuncture; safety; toxicity
Citation
Journal of Acupuncture Research, v.37, no.3, pp.167 - 172
Journal Title
Journal of Acupuncture Research
Volume
37
Number
3
Start Page
167
End Page
172
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78095
DOI
10.13045/jar.2020.00185
ISSN
2586-288X
Abstract
Background: This study aimed to assess the toxicity of capsaicin (CP) pharmacopunture in an animal model. Methods: The toxicity of a single-muscular dose of CP (45.45 mg/mL) was evaluated in 6-week-old male and female Sprague-Dawley rats. A total of 20 rats were assigned to 2 groups which were sex and weight matched. All rats acclimatized for 1 week before receiving 1.0 mL of CP (45.45 mg/mL) or normal saline solution (control) intramuscularly. The general condition and mortality of the animals were observed. The rats were sacrificed 2 weeks after CP was administered and histopathology was performed. Results: No abnormal symptoms or deaths were observed, and there was no difference in body weights between the CP and control groups throughout the study. No significant differences in histopathology were observed between the groups. Conclusion: No toxicological changes related to the administration of CP were observed. This study indicated that the safe dose of CP in Sprague-Dawley rats was 1.0 mL of CP (45.45 mg/mL) or less. Further studies are needed to confirm the safety of CP in the human body.
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College of Korean Medicine (Dept.of Korean Medicine)
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