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A Successful Application of Phosphazene Base P2-tBu to [11C]ABP688 Radiosynthesis in Fully Automated Synthesis Module
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, Jihye | - |
| dc.date.available | 2020-09-01T05:35:12Z | - |
| dc.date.created | 2020-08-24 | - |
| dc.date.issued | 2020-08 | - |
| dc.identifier.issn | 0253-2964 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78112 | - |
| dc.description.abstract | [11C]ABP688 is the radioligand widely used for metabotropic glutamate subtype 5 (mGluR5) imaging in positron emission tomography (PET). The successful production of [11C]ABP688 in commercial automated synthesis module with hindered strong organic base was achieved. I compared 1,8-bis(tetramethylguanidino)naphthalene (TMGN), tert-butylimino-tri(pyrrolidino)phosphorane (BTPP), P2-tBu, P4-tBu, and NaH as a base for C-11 methylation of oxime and found P2-tBu would be a suitable alternative for the conventional inorganic bases (NaH or NaOH). Considering the GMP application, P2-tBu can provide compatibility with automated synthesizer and the resulting reliable synthesis. Three batches of the optimized condition for [11C]ABP688 synthesis were examined for quality assurance. © 2020 Korean Chemical Society, Seoul & Wiley-VCH GmbH | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | Wiley Blackwell | - |
| dc.relation.isPartOf | Bulletin of the Korean Chemical Society | - |
| dc.title | A Successful Application of Phosphazene Base P2-tBu to [11C]ABP688 Radiosynthesis in Fully Automated Synthesis Module | - |
| dc.type | Article | - |
| dc.type.rims | ART | - |
| dc.description.journalClass | 1 | - |
| dc.identifier.wosid | 000560003700001 | - |
| dc.identifier.doi | 10.1002/bkcs.12070 | - |
| dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.41, no.8, pp.799 - 804 | - |
| dc.identifier.kciid | ART002614407 | - |
| dc.description.isOpenAccess | N | - |
| dc.identifier.scopusid | 2-s2.0-85089461616 | - |
| dc.citation.endPage | 804 | - |
| dc.citation.startPage | 799 | - |
| dc.citation.title | Bulletin of the Korean Chemical Society | - |
| dc.citation.volume | 41 | - |
| dc.citation.number | 8 | - |
| dc.contributor.affiliatedAuthor | Lee, Jihye | - |
| dc.type.docType | Article | - |
| dc.subject.keywordAuthor | ABP688 | - |
| dc.subject.keywordAuthor | mGluR5 | - |
| dc.subject.keywordAuthor | P2-tBu | - |
| dc.subject.keywordAuthor | Phosphazene base | - |
| dc.subject.keywordAuthor | [11C]methylation | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
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