Phallac acids A and B, new sesquiterpenes from the fruiting bodies of Phallus luteus
DC Field | Value | Language |
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dc.contributor.author | Lee S.R. | - |
dc.contributor.author | Lee D. | - |
dc.contributor.author | Lee B.S. | - |
dc.contributor.author | Ryoo R. | - |
dc.contributor.author | Pang C. | - |
dc.contributor.author | Kang K.S. | - |
dc.contributor.author | Kim K.H. | - |
dc.date.available | 2020-09-14T01:35:26Z | - |
dc.date.created | 2020-06-08 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0021-8820 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78196 | - |
dc.description.abstract | Phallus luteus (Phallaceae), previously known as Dictyophora indusiata, is an edible and medicinal mushroom. As part of a continuing project to discover structurally and/or biologically novel natural products from wild mushrooms, we aimed to perform a chemical investigation of the methanol extract of P. luteus combined with a liquid chromatography–mass spectrometry-guided analysis coupled to an in-house UV spectral library. Two new sesquiterpenes, phallac acids A (1) and B (2), were isolated and determined. The chemical structure of the new natural products was unambiguously determined using a combination of 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry data. To our knowledge, this is the first study to report linear sesquiterpene carboxylic acids from P. luteus. The new compounds were evaluated for α-glucosidase inhibitory activities where phallac acid B (2) showed α-glucosidase inhibitory potential (IC50 value of 94.89 ± 5.57 μM) compared with the standard acarbose (IC50 value of 26.23 ± 1.31 μM). © 2020, The Author(s), under exclusive licence to the Japan Antibiotics Research Association. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Springer Nature | - |
dc.relation.isPartOf | Journal of Antibiotics | - |
dc.title | Phallac acids A and B, new sesquiterpenes from the fruiting bodies of Phallus luteus | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000559846300001 | - |
dc.identifier.doi | 10.1038/s41429-020-0328-z | - |
dc.identifier.bibliographicCitation | Journal of Antibiotics, v.73, no.10, pp.729 - 732 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85085564742 | - |
dc.citation.endPage | 732 | - |
dc.citation.startPage | 729 | - |
dc.citation.title | Journal of Antibiotics | - |
dc.citation.volume | 73 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Lee D. | - |
dc.contributor.affiliatedAuthor | Kang K.S. | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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