A label-free liquid crystal droplet-based sensor used to detect lead ions using single-stranded DNAzyme
- Authors
- Duong, T.D.S.; Jang, C.-H.
- Issue Date
- Nov-2020
- Publisher
- Elsevier B.V.
- Keywords
- 4-cyano-4’-pentylbiphenyl (5CB); DNAzyme; Droplet patterns; Heavy metal; Lead ions (Pb2+); Liquid crystal (LC)
- Citation
- Colloids and Surfaces A: Physicochemical and Engineering Aspects, v.604
- Journal Title
- Colloids and Surfaces A: Physicochemical and Engineering Aspects
- Volume
- 604
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78302
- DOI
- 10.1016/j.colsurfa.2020.125304
- ISSN
- 0927-7757
- Abstract
- A liquid crystal (LC) droplet pattern-based sensor used to detect lead ions (Pb2+) in phosphate buffer saline (PBS) solution using single-stranded DNAzyme has been reported. When Pb2+ were present, it bound to the DNAzyme, leading to the release of tetradecyltrimethylammonium bromide (OTAB). These OTAB molecules were absorbed onto the aqueous/LC interface and helped in arranging the LC orientation. A planar-to-homeotropic order transition of LC droplets was triggered during this event. The reported naked-eye optical sensor possesses a limit of detection (LOD) of about 0.7 nM in PBS and 0.8 nM in tap water. The proposed LC droplet-based sensor was highly sensitive and selective for label-free Pb2+ detection. This sensor also provided a platform for the detection of proteins, DNA, and other metal ions by modifying the receptor. © 2020 Elsevier B.V.
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