An in vivo proton magnetic resonance spectroscopy study with optimized echo-time technique for concurrent quantification and T2 measurement targeting glutamate in the rat brain
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Chi-Hyeon | - |
dc.contributor.author | Baek, Hyeon-Man | - |
dc.contributor.author | Song, Kyu-Ho | - |
dc.contributor.author | Woo, Dong-Cheol | - |
dc.contributor.author | Choe, Bo-Young | - |
dc.date.available | 2020-10-20T00:59:17Z | - |
dc.date.created | 2020-04-20 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0968-5243 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78319 | - |
dc.description.abstract | Objective The present study applied in vivo proton magnetic resonance spectroscopy (H-1 MRS) to concurrently measure the concentration and T2 relaxation time of glutamate with the concept of optimized-for-quantification-and-T2-measurement-of-glutamate (OpQT2-Glu). Materials and methods 7T MRS scans of the OpQT2-Glu were acquired from the prefrontal cortex of five rats. The echo-time-(TE)-specific J-modulation of glutamate was investigated by spectral simulations and analyses for selecting the eight TEs appropriate for T2 estimation of glutamate. The OpQT2-Glu results were compared to those of the typical short-TE MRS and T2 measurements. Results No significant differences were observed between the OpQT2-Glu and typical short-TE MRS (p > 0.050). The estimated glutamate T2 (67.75 ms) of the OpQT2-Glu was similar to the multiple TE MRS for the T2 measurement (71.58 ms) with enhanced signal-to-noise ratio and reliability. Discussion The results revealed that the quantification reliability of the OpQT2-Glu was comparable to that of the single short-TE MRS and its estimation reliability for the T2 relaxation time of glutamate was enhanced compared to the multiple TE MRS for T2 measurement. Despite certain limitations, the quantification and T2 estimation of glutamate can be concurrently performed within an acceptable scan time via high-field in vivo H-1 MRS with the OpQT2-Glu. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE | - |
dc.title | An in vivo proton magnetic resonance spectroscopy study with optimized echo-time technique for concurrent quantification and T2 measurement targeting glutamate in the rat brain | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000523092600001 | - |
dc.identifier.doi | 10.1007/s10334-020-00840-w | - |
dc.identifier.bibliographicCitation | MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, v.33, no.5, pp.735 - 746 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85083284869 | - |
dc.citation.endPage | 746 | - |
dc.citation.startPage | 735 | - |
dc.citation.title | MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE | - |
dc.citation.volume | 33 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Yoo, Chi-Hyeon | - |
dc.contributor.affiliatedAuthor | Baek, Hyeon-Man | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | In vivo proton magnetic resonance spectroscopy | - |
dc.subject.keywordAuthor | Glutamate | - |
dc.subject.keywordAuthor | Brain metabolism and microenvironment | - |
dc.subject.keywordPlus | T-2 RELAXATION | - |
dc.subject.keywordPlus | METABOLITE CONCENTRATIONS | - |
dc.subject.keywordPlus | PARAMETERS | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | SPECTRA | - |
dc.subject.keywordPlus | FIELD | - |
dc.subject.keywordPlus | MRS | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.