Anti-inflammatory Effect of Water-soluble Chitosan Oligosaccharideson Human Monocyte THP-1 Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Que Thanh Thanh Nguyen | - |
dc.contributor.author | Thi Xoan Hoang | - |
dc.contributor.author | 박제권 | - |
dc.contributor.author | 김재영 | - |
dc.date.available | 2020-10-20T01:02:02Z | - |
dc.date.created | 2020-09-28 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1229-4160 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78391 | - |
dc.description.abstract | The various functional properties of chitosan have been investigated for use in biomedical applications. Indeed, chitosan or its derivatives have shown anti-inflammatory effect by regulating a range of cytokines, chemokines or growth factors. In the present study, we prepared water-soluble chitosan oligosaccharide (AS-WSC) by the hydrolysis of high molecular weight water-soluble chitosan (HMW-WSC) and examined its anti-inflammatory effect on LPS-stimulated human monocytic THP-1 cells. Our results revealed that LPS-induced NF-κB activity of THP-1 cells was significantly suppressed by treatment with 0.02% AS-WSC. In addition, 0.02% AS-WSC treatment down-regulated the expression of Toll-like receptor 4 and inflammatory cytokines, such as IL-1β and TNF-α, but had no effect on IL-10 and IL-4 expression in LPS-stimulated THP-1 cells. Our results suggest that 0.02% AS-WSC can be considered as a promising anti-inflammatory agent. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국키틴키토산학회 | - |
dc.relation.isPartOf | Journal of Chitin and Chitosan | - |
dc.title | Anti-inflammatory Effect of Water-soluble Chitosan Oligosaccharideson Human Monocyte THP-1 Cells | - |
dc.title.alternative | Anti-inflammatory Effect of Water-soluble Chitosan Oligosaccharideson Human Monocyte THP-1 Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | Journal of Chitin and Chitosan, v.25, no.3, pp.143 - 147 | - |
dc.identifier.kciid | ART002626608 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 147 | - |
dc.citation.startPage | 143 | - |
dc.citation.title | Journal of Chitin and Chitosan | - |
dc.citation.volume | 25 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Que Thanh Thanh Nguyen | - |
dc.contributor.affiliatedAuthor | Thi Xoan Hoang | - |
dc.contributor.affiliatedAuthor | 박제권 | - |
dc.contributor.affiliatedAuthor | 김재영 | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordAuthor | Monocyte | - |
dc.subject.keywordAuthor | Toll-like receptor 4 | - |
dc.subject.keywordAuthor | NF-kappaB | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.description.journalRegisteredClass | kci | - |
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