Traditional Korean diet can alter the urine organic acid profile, which may reflect the metabolic influence of the diet
DC Field | Value | Language |
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dc.contributor.author | 신필경 | - |
dc.contributor.author | 천수경 | - |
dc.contributor.author | 김명선 | - |
dc.contributor.author | 박선주 | - |
dc.contributor.author | 김민정 | - |
dc.contributor.author | 권대영 | - |
dc.contributor.author | 김경철 | - |
dc.contributor.author | 이해정 | - |
dc.contributor.author | 최상운 | - |
dc.date.available | 2020-10-20T01:03:44Z | - |
dc.date.created | 2020-07-07 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 2288-3886 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78428 | - |
dc.description.abstract | Purpose: To determine the metabolic influence of the traditional Korean diet (K-diet), which has been regarded as a healthy diet, we investigated the profile of urine organic acids that are intermediates of various types of metabolism including energy metabolism. Methods: Ten women aged 50–60 years were recruited and randomly divided into 2 diet groups, K-diet and control diet, the latter of which is a Westernized Korean diet that is commonly consumed by Koreans nowadays. Before and after the 2-week intervention, 46 urine organic acids were determined using LC/MS/MS, along with clinical parameters. Results: The average concentrations of succinate (4.14 ± 0.84 µg/mg creatinine vs. 1.49 ± 0.11, p = 0.0346) and hydroxymethylglutarate (3.67 ± 0.36 µg/mg creatinine vs. 2.97 ± 0.29, p = 0.0466), both of which are intermediates of energy metabolism, decreased in the K-diet group after the 2-week intervention, but these were not observed in the control diet group. In particular, the average concentration of succinate in the K-diet group was lower than that in the control group (3.33 ± 0.56 µg/mg creatinine vs. 1.49 ± 0.11, p = 0.0284) after 2 weeks. The concentrations of two tryptophan metabolites, 5-hydroxyindolacetate (3.72 ± 0.22 µg/mg creatinine vs. 3.14 ± 0.21, p = 0.0183) and indican (76.99 ± 8.35 µg/mg creatinine vs. 37.89 ± 10.06, p = 0.0205) also decreased only in the K-diet group. After the 2-week intervention, the concentration of kynurenate, another tryptophan metabolite, was lower in the K-diet group than that in the control diet group (3.96 ± 0.51 µg/mg creatinine vs. 2.90 ± 0.22, p = 0.0356). Interestingly, the urine level of kynurenate was positively correlated with BMI (r = 0.61424, p = 0.0003) and total cholesterol (r = 0.46979, p = 0.0088), which decreased only in the K-diet group (239.40 ± 15.14 mg/dL vs. 198.20 ± 13.25, p = 0.0163). Conclusion: The K-diet alters the urinary excretion of organic acids involved in energy metabolism and tryptophan metabolism, suggesting the influence of the K-diet on these types of metabolism. Urine organic acids changed by the K-diet may serve as biomarkers in future studies. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 한국영양학회 | - |
dc.relation.isPartOf | Journal of Nutrition and Health | - |
dc.title | Traditional Korean diet can alter the urine organic acid profile, which may reflect the metabolic influence of the diet | - |
dc.title.alternative | 한식의 체내 대사에 미치는 영향에 대한 연구 : 소변 유기산 분석을 통한 한식의 효과 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.4163/jnh.2020.53.3.231 | - |
dc.identifier.bibliographicCitation | Journal of Nutrition and Health, v.53, no.3, pp.231 - 243 | - |
dc.identifier.kciid | ART002605639 | - |
dc.identifier.scopusid | 2-s2.0-85089685956 | - |
dc.citation.endPage | 243 | - |
dc.citation.startPage | 231 | - |
dc.citation.title | Journal of Nutrition and Health | - |
dc.citation.volume | 53 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 박선주 | - |
dc.contributor.affiliatedAuthor | 이해정 | - |
dc.subject.keywordAuthor | Korean diet | - |
dc.subject.keywordAuthor | urine organic acid | - |
dc.subject.keywordAuthor | succinate | - |
dc.subject.keywordAuthor | hydroxymethylglutarate | - |
dc.subject.keywordAuthor | kynurenate | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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