Brain network connectivity and association with catechol-o-methyltransferase gene polymorphism in Korean attention-deficit hyperactivity disorder children
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, J.H. | - |
dc.contributor.author | Son, Y.D. | - |
dc.contributor.author | Kim, Y. | - |
dc.contributor.author | Han, D.H. | - |
dc.date.available | 2020-10-20T02:46:17Z | - |
dc.date.created | 2020-09-25 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78448 | - |
dc.description.abstract | Objective We sought to determine if the links between and within the default mode network (DMN) and dorsal attention network (DAT) exhibited different conditions according to catechol-O-methyltransferase (COMT) gene polymorphism in relationship to atten-tion-deficit hyperactivity disorder (ADHD) symptoms. Methods Fifty-seven children with ADHD and 48 healthy controls (HCs) were administered an intelligence test, the Children’s Depression Inventory, the Korean ADHD rating scale, and continuous performance test. Resting-state brain functional MRI scans were obtained, and COMT genotyping was performed to distinguish valine carriers and methionine homozygotes. Results Compared to controls, children with ADHD showed increased ADHD scale scores, increased visual commission errors, and increased functional connectivity (FC) within the DMN and DAT. Compared to all children with ADHD, children with the methionine homozygote and those who were valine carriers showed increased FC within the DMN and DAT and decreased FC between the DMN and DAT. FC within the DMN was also increased in HC valine carriers compared to HC children with the methionine homozygote, and in children with ADHD who were valine carriers compared to HC valine carriers. Conclusion We observed increased brain connectivity within the DMN and DAT and altered brain connectivity within and between the DMN and DAT associated with COMT polymorphism in children with ADHD. Psychiatry Investig 2020;17(9):925-933. © 2020 Korean Neuropsychiatric Association. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Neuropsychiatric Association | - |
dc.relation.isPartOf | Psychiatry Investigation | - |
dc.title | Brain network connectivity and association with catechol-o-methyltransferase gene polymorphism in Korean attention-deficit hyperactivity disorder children | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000575387000010 | - |
dc.identifier.doi | 10.30773/pi.2020.0132 | - |
dc.identifier.bibliographicCitation | Psychiatry Investigation, v.17, no.9, pp.925 - 933 | - |
dc.identifier.kciid | ART002626619 | - |
dc.identifier.scopusid | 2-s2.0-85091068326 | - |
dc.citation.endPage | 933 | - |
dc.citation.startPage | 925 | - |
dc.citation.title | Psychiatry Investigation | - |
dc.citation.volume | 17 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Son, Y.D. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Attention-deficit hyperactivity disorder | - |
dc.subject.keywordAuthor | Catechol-O-methyltransferase | - |
dc.subject.keywordAuthor | Default mode network | - |
dc.subject.keywordAuthor | Dorsal attention network | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.