Synthesis of Silver Nanoparticles using Euphorbia wallichii Extract and Assessment of their Bio-functionalities
DC Field | Value | Language |
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dc.contributor.author | Phull, Abdul-Rehman | - |
dc.contributor.author | Ali, Attarad | - |
dc.contributor.author | Ali, Akhtar | - |
dc.contributor.author | Abbasi, Sanaullah | - |
dc.contributor.author | Zia, Muhammad | - |
dc.contributor.author | Khaskheli, Muhammad H. | - |
dc.contributor.author | Ul Haq, Ihsan | - |
dc.contributor.author | Kamal, Mohammad A. | - |
dc.date.available | 2020-10-20T06:42:23Z | - |
dc.date.created | 2020-08-31 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 1573-4064 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78487 | - |
dc.description.abstract | Background: Silver nanoparticles synthesized by the bio-green method have been applied to various biomedical applications. These procedures are simple, eco-friendly and serve as an alternative to complex chemical methods for the preparation of nanomaterials. Objective: In the present study, phytosynthesis of silver nanoparticles, to examine their antioxidant potential, toxic effects towards bacterial-, fimgal-strains, brine shrimp nauplii and cancer cells was focused. Methods: Methanolic extract of Euphorbia wallichii roots was used for the synthesis of silver nanoparticles. The synthesis was monitored and confirmed by UV-visible spectroscopy, Fourier Transform Infra-Red (FTIR) spectrometric analysis, Field Emission Scanning Electron Microscope (FESEM), Energy Dispersive X-ray (EDX) and X-Ray Powder Diffraction (XRD). Results: The synthesized particles were average 63 +/- 8 nm in size. Involvement of phenolic (46.7+2.4 mu g GAE/mg) and flavonoid (11.7+1.2 mu g QE/mg) compounds as capping agents was also measured. Nanoparticles showed antioxidant properties in terms of free radical scavenging potential (59.63+1.0 %), reducing power (44.52 +/- 1.34 mu g AAE/mg) and total antioxidant capacity (60.48 +/- 2.2 mu g AAE/mg). The nanoparticles showed potent cytotoxic effects against brine shrimp nauplii (LD50 66.83 mu g/ml), proliferation and cell death of HeLa cells as determined by MIT (LD50 0.3923 mu g/ml) and TUNEL assays, respectively. Antimicrobial results revealed that silver nanoparticles were found to be more potent against pathogenic fungal (maximum active against A. fumigatus, MIC 15 mu g/disc) and bacterial strains (maximum active against S. aureus, MIC 3.33 mu g/disc) than the E. wallichii extract alone. Conclusion: These results support the advantages of using an eco-friendly and cost-effective method for synthesis of nanoparticles with antioxidant, cytotoxic and antimicrobial potential. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BENTHAM SCIENCE PUBL LTD | - |
dc.relation.isPartOf | MEDICINAL CHEMISTRY | - |
dc.title | Synthesis of Silver Nanoparticles using Euphorbia wallichii Extract and Assessment of their Bio-functionalities | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000536018300004 | - |
dc.identifier.doi | 10.2174/1573406415666191111143213 | - |
dc.identifier.bibliographicCitation | MEDICINAL CHEMISTRY, v.16, no.4, pp.495 - 506 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 506 | - |
dc.citation.startPage | 495 | - |
dc.citation.title | MEDICINAL CHEMISTRY | - |
dc.citation.volume | 16 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Phull, Abdul-Rehman | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Antimicrobial | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | Euphorbia wallichii | - |
dc.subject.keywordAuthor | HeLa cells | - |
dc.subject.keywordAuthor | silver nanoparticles | - |
dc.subject.keywordPlus | GREEN SYNTHESIS | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | LEAF EXTRACT | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | AG | - |
dc.subject.keywordPlus | ANTIBACTERIAL | - |
dc.subject.keywordPlus | AU | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | PLANTS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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