Parallel Detection of Anti-Tuberculosis Antibodies upon a Liquid Crystal-based Optical Sensor
DC Field | Value | Language |
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dc.contributor.author | Rim, Jinseob | - |
dc.contributor.author | Kim, Hyeong Jin | - |
dc.contributor.author | Jang, Chang-Hyun | - |
dc.date.available | 2020-02-28T00:43:11Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7848 | - |
dc.description.abstract | In the present study, we developed a label-free liquid crystal (LC)-based system to simultaneously detect anti-tuberculosis (TB) antibodies against multiple antigens. Multiple TB antigens were discretely immobilized on a substrate with nano-patterns replicated from a buckled poly(dimethylsiloxane) to orient LCs uniformly. After the antibody solution was introduced to surface-immobilized antigens, non-specific antibodies did not have any effect on the orientation of LCs; however, the antigen-antibody complexes formed by specific interactions disturbed the orientation of LCs by masking the anisotropic surface topography. The orientational behavior of LCs was visualized with a polarizing optical microscope. The limit of detection was from 0.15 to 1.5 mu g/mL. With this method, antibodies in the solution of interest can be identified, which will facilitate the development of a new diagnostic approach for TB. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.subject | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject | PULMONARY TUBERCULOSIS | - |
dc.subject | DIAGNOSIS | - |
dc.subject | SERODIAGNOSIS | - |
dc.subject | ANTIGENS | - |
dc.subject | SURFACE | - |
dc.subject | TESTS | - |
dc.title | Parallel Detection of Anti-Tuberculosis Antibodies upon a Liquid Crystal-based Optical Sensor | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000385716500019 | - |
dc.identifier.doi | 10.1002/bkcs.10922 | - |
dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.10, pp.1644 - 1651 | - |
dc.identifier.kciid | ART002152356 | - |
dc.identifier.scopusid | 2-s2.0-84988888033 | - |
dc.citation.endPage | 1651 | - |
dc.citation.startPage | 1644 | - |
dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.volume | 37 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Rim, Jinseob | - |
dc.contributor.affiliatedAuthor | Kim, Hyeong Jin | - |
dc.contributor.affiliatedAuthor | Jang, Chang-Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Liquid crystals (LCs) | - |
dc.subject.keywordAuthor | 4-cyano-4-pentylbiphenyl (5CB) | - |
dc.subject.keywordAuthor | Polymeric substrates | - |
dc.subject.keywordAuthor | Tuberculosis (TB) | - |
dc.subject.keywordAuthor | Parallel detection | - |
dc.subject.keywordPlus | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject.keywordPlus | PULMONARY TUBERCULOSIS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | SERODIAGNOSIS | - |
dc.subject.keywordPlus | ANTIGENS | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | TESTS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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