Ferritin Level Is Positively Associated with Chronic Kidney Disease in Korean Men, Based on the 2010-2012 Korean National Health and Nutrition Examination Survey
- Authors
- Kang, Hee-Taik; Linton, John A.; Kwon, Soon Kil; Park, Byoung-Jin; Lee, Jong Hun
- Issue Date
- Nov-2016
- Publisher
- MDPI
- Keywords
- ferritin; oxidative stress; inflammation; chronic kidney disease; iron
- Citation
- INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.13, no.11
- Journal Title
- INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
- Volume
- 13
- Number
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78684
- DOI
- 10.3390/ijerph13111058
- ISSN
- 1661-7827
1660-4601
- Abstract
- (1) Background: Oxidative stress and inflammation are associated with higher risk of chronic kidney disease (CKD). Serum ferritin concentrations correlate with total iron levels and systemic inflammation. (2) Methods: This study was cross-sectionally designed, based on the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES). According to ferritin values, 13,462 participants (6082 men and 7380 women) were categorized into the normal-and high-ferritin groups (cut-off points: 200 ng/mL in men, 150 ng/mL in women). (3) Results: The mean ages of men and women were 44.5 and 48.4 years, respectively. The percentage of participants categorized into the high-ferritin group was 15.1% for men and 3.6% for women. The estimated glomerular filtration rate levels in the normal-and high-ferritin groups were 93.2 and 93.8 mL/min/1.73 m(2) for men and 97.1 and 87.7 mL/min/1.73 m(2) for women, respectively. The prevalence of CKD in the normal-and high-ferritin groups was 2.6% and 3.9% for men and 3.2% and 8.1% for women, respectively. Compared with the normal-ferritin group, the odds ratios (95% confidence intervals) for CKD of the high-ferritin group were 1.573 (1.014-2.441) in men and 1.061 (0.381-2.955) in women, after adjustments for age and other covariates. (4) Conclusions: High ferritin levels were associated with a higher risk of CKD in men but not in women.
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Collections - 바이오나노대학 > 식품생물공학과 > 1. Journal Articles
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