Flavonoids and a Limonoid from the Fruits of Citrus unshiu and Their Biological Activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Eom, Hee Jeong | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Lee, Seulah | - |
dc.contributor.author | Noh, Hyung Jun | - |
dc.contributor.author | Hyun, Jae Wook | - |
dc.contributor.author | Yi, Pyoung Ho | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.available | 2020-02-28T00:43:33Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-09-28 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7872 | - |
dc.description.abstract | The fruits of Citrus unshiu are one of the most popular and most enjoyed fruits in Korea. As we continue to seek for bioactive metabolites from Korean natural resources, our study on the chemical constituents of the fruits of C. unshiu resulted in the isolation of a new flavonoid glycoside, limocitrunshin 1, along with seven other flavonoids 2-8 and a limonoid 9. All structures were identified by spectroscopic methods, namely 1D and 2D NMR, including HSQC, HMBC, and H-1-H-1 COSY experiments, HRMS, and other chemical methods. Compounds 3, 5, and 9 are reported to be isolated from this fruit for the first time. The isolated compounds were applied to activity tests to verify their inhibitory effects on inflammation and nephrotoxicity. Compounds 6 and 9 showed the most potent inhibitory activity on renal cell damage and nitric oxide production, respectively. Thus, the fruits of C. unshiu could serve as a valuable natural source of bioactive components with health benefits for potential application in functional foods. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.subject | CISPLATIN-INDUCED NEPHROTOXICITY | - |
dc.subject | NITRIC-OXIDE PRODUCTION | - |
dc.subject | LANOSTANE TRITERPENOIDS | - |
dc.subject | ANTIOXIDANT ACTIVITY | - |
dc.subject | INHIBITORY-ACTIVITY | - |
dc.subject | MURINE MACROPHAGES | - |
dc.subject | RAW 264.7 | - |
dc.subject | GLYCOSIDES | - |
dc.subject | PEELS | - |
dc.subject | CONSTITUENTS | - |
dc.title | Flavonoids and a Limonoid from the Fruits of Citrus unshiu and Their Biological Activity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000384518200015 | - |
dc.identifier.doi | 10.1021/acs.jafc.6b03465 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.64, no.38, pp.7171 - 7178 | - |
dc.identifier.scopusid | 2-s2.0-84989267346 | - |
dc.citation.endPage | 7178 | - |
dc.citation.startPage | 7171 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 38 | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Citrus unshiu | - |
dc.subject.keywordAuthor | Rutaceae | - |
dc.subject.keywordAuthor | flavonoid | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | nephrotoxicity | - |
dc.subject.keywordPlus | CISPLATIN-INDUCED NEPHROTOXICITY | - |
dc.subject.keywordPlus | NITRIC-OXIDE PRODUCTION | - |
dc.subject.keywordPlus | LANOSTANE TRITERPENOIDS | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | INHIBITORY-ACTIVITY | - |
dc.subject.keywordPlus | MURINE MACROPHAGES | - |
dc.subject.keywordPlus | RAW 264.7 | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | PEELS | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.