The omega-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of beta-catenin complex, inhibiting COX-2 through repressing NF-kappa B, and inducing 15-prostaglandin dehydrogenase
DC Field | Value | Language |
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dc.contributor.author | Han, Young-Min | - |
dc.contributor.author | Jeong, Migyeung | - |
dc.contributor.author | Park, Jong-Min | - |
dc.contributor.author | Kim, Mi-Young | - |
dc.contributor.author | Go, Eun-Jin | - |
dc.contributor.author | Cha, Ji Young | - |
dc.contributor.author | Kim, Kyung Jo | - |
dc.contributor.author | Hahm, Ki Baik | - |
dc.date.available | 2020-02-28T00:43:35Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-09-27 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7875 | - |
dc.description.abstract | Numerous studies have demonstrated that diets containing an increased ratio of omega-6 : omega-3 polyunsaturated fatty acids ( PUFAs) are a risk factor for colon cancer and might affect tumorigenesis. Therefore, dietary omega-3 PUFA administration may be a preventive strategy against colon cancer. Until now, the exact molecular mechanisms and required dietary doses of -3 PUFAs for cancer prevention were unknown. In this study, we explored the anti-tumorigenic mechanisms of omega-3 PUFAs against a colitis-associated cancer (CAC) model. Through in vitro cell models involving docosahexaenoic acid (DHA) administration, down-regulation of survivin and Bcl-2, and up-regulation of Bax, accompanied by blockage of beta-catenin complex dissociation, the main mechanisms responsible for DHA-induced apoptosis in HCT116 cells were determined. Results included significant reduction in azoxymethane-initiated, dextran sodium sulfatepromoted CACs, as well as significant preservation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and significant inhibition of Cyclooxyganase-2 (COX-2) and Prostaglandin E-2 (P < 0.01). Additional mechanisms and significant induction of apoptosis in both tumor and non-tumor tissues were also noted in fat-1 transgenic (TG) mice. The lipid profiles of colon tissues measured in all specimens revealed that intake greater than 3 g omega-3 PUFA/60 kg of body weight showed tissue levels similar to those seen in fat-1 TG mice, preventing cancer. Our study concluded that COX2 inhibition, 15-PGDH preservation, apoptosis induction, and blockage of beta-catenin complex dissociation contributed to the anti-tumorigenesis effect of omega-3 PUFAs, and an intake higher than 3g omega-3 PUFAs/60 kg of body weight can assist in CAC prevention. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.subject | FAT-1 TRANSGENIC MICE | - |
dc.subject | CANCER | - |
dc.subject | TUMORIGENESIS | - |
dc.subject | GROWTH | - |
dc.subject | INFLAMMATION | - |
dc.subject | DESATURASE | - |
dc.subject | EXPRESSION | - |
dc.subject | MODEL | - |
dc.subject | RATIO | - |
dc.subject | RICH | - |
dc.title | The omega-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of beta-catenin complex, inhibiting COX-2 through repressing NF-kappa B, and inducing 15-prostaglandin dehydrogenase | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000387167800060 | - |
dc.identifier.doi | 10.18632/oncotarget.11544 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.7, no.39, pp.63583 - 63595 | - |
dc.identifier.scopusid | 2-s2.0-84994056098 | - |
dc.citation.endPage | 63595 | - |
dc.citation.startPage | 63583 | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 7 | - |
dc.citation.number | 39 | - |
dc.contributor.affiliatedAuthor | Cha, Ji Young | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | fat-1 transgenic mice | - |
dc.subject.keywordAuthor | colitic cancer | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | omega-3 PUFAs | - |
dc.subject.keywordAuthor | 15-PGDH | - |
dc.subject.keywordAuthor | beta-catenin complex | - |
dc.subject.keywordPlus | FAT-1 TRANSGENIC MICE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TUMORIGENESIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DESATURASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | RATIO | - |
dc.subject.keywordPlus | RICH | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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