치매 치료 보조제로서 커큐민의 유효성 및 안전성에 대한 문헌고찰

Abstract

Curcumin is a polyphenol compound derived from Curcuma longa and possesses potential for alternative optionin the management of Alzheimer’s disease. In this literature review, we aimed to evaluate results reported in clinicalstudies, particularly focusing on efficacy and safety of curcumin in the management of Alzheimer’s disease. A total of 806articles were searched in the Pubmed and clinicaltrials.gov databases. Four records of the articles were clinically relatedwith Alzheimer’s disease: two phase 1 studies, two phase 2 studies, and all of which being randomized placebo-controlledprospective studies. In phase 1 studies with elderly population having no memory or cognition impairment, curcuminshowed beneficial effect on mood and cognition. However, in phase 2 studies with Alzheimer’s disease patients havingmemory and cognition loss, curcumin failed to show benefits. The inconsistent results might be probably because of shortstudy duration as well as quality differences of curcumin products used in clinical studies. In conclusion, althoughcurcumin might be an alternative option in the prevention of the Alzheimer’s disease, further research is warranted tomatch in-vitro results with clinical outcomes.