Increased neuritogenesis on ternary nanofiber matrices of PLCL and laminin decorated with black phosphorus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, M.S. | - |
dc.contributor.author | Song, S.-J. | - |
dc.contributor.author | Cha, J.H. | - |
dc.contributor.author | Cho, Y. | - |
dc.contributor.author | Lee, H.U. | - |
dc.contributor.author | Hyon, S.-H. | - |
dc.contributor.author | Lee, J.H. | - |
dc.contributor.author | Han, D.-W. | - |
dc.date.available | 2020-11-04T05:40:33Z | - |
dc.date.created | 2020-10-12 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78823 | - |
dc.description.abstract | Recently, the composites of varying biomaterials and two-dimensional (2D) nanomaterials have been increasingly developed in the field of tissue engineering and regeneration owing to their excellent physicochemical and mechanical properties. In particular, the combination of biocompatible polymers and 2D nanomaterials can endow the nanocomposite with novel biofunctional properties while maintaining the inherent character of every single material. These nanocomposites are known to have the potential for improvement of cellular behaviors such as cell adhesion, proliferation, and differentiation. In this study, poly(l-lactide-co-ε-caprolactone) (PLCL) and laminin (Lam) nanofibers functionalized with black phosphorus (BP) were successfully fabricated to increase the neuritogenesis of HT22 hippocampal neuronal cells using an electrospinning process. The ternary nanofiber matrices of PLCL/Lam/BP were found to be suitable for supporting the attachment and proliferation of hippocampal neurons. Furthermore, these PLCL/Lam/BP nanofiber matrices could not only promote neurite outgrowth and alignment but also increase the neuritogenesis of hippocampal neurons by providing optimal microenvironments for neuronal differentiation. The underlying mechanism of this phenomenon was confirmed by determining the expression levels of genes related to neurogenesis. In conclusion, these results suggest that BP-functionalized composite nanofibers could be a promising candidate as a scaffold for neural tissue engineering and regeneration. © 2020 The Korean Society of Industrial and Engineering Chemistry | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | Journal of Industrial and Engineering Chemistry | - |
dc.title | Increased neuritogenesis on ternary nanofiber matrices of PLCL and laminin decorated with black phosphorus | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000580635100022 | - |
dc.identifier.doi | 10.1016/j.jiec.2020.09.009 | - |
dc.identifier.bibliographicCitation | Journal of Industrial and Engineering Chemistry, v.92, pp.226 - 235 | - |
dc.identifier.kciid | ART002680010 | - |
dc.identifier.scopusid | 2-s2.0-85092014131 | - |
dc.citation.endPage | 235 | - |
dc.citation.startPage | 226 | - |
dc.citation.title | Journal of Industrial and Engineering Chemistry | - |
dc.citation.volume | 92 | - |
dc.contributor.affiliatedAuthor | Cha, J.H. | - |
dc.contributor.affiliatedAuthor | Cho, Y. | - |
dc.contributor.affiliatedAuthor | Lee, J.H. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Black phosphorus | - |
dc.subject.keywordAuthor | Laminin | - |
dc.subject.keywordAuthor | Nanofiber matrices | - |
dc.subject.keywordAuthor | Neural tissue engineering | - |
dc.subject.keywordAuthor | Two-dimensional nanomaterials | - |
dc.subject.keywordPlus | Biocompatibility | - |
dc.subject.keywordPlus | Biomechanics | - |
dc.subject.keywordPlus | Black Phosphorus | - |
dc.subject.keywordPlus | Cell adhesion | - |
dc.subject.keywordPlus | Nanocomposites | - |
dc.subject.keywordPlus | Nanofibers | - |
dc.subject.keywordPlus | Phosphorus | - |
dc.subject.keywordPlus | Physicochemical properties | - |
dc.subject.keywordPlus | Scaffolds (biology) | - |
dc.subject.keywordPlus | Tissue | - |
dc.subject.keywordPlus | Biocompatible polymer | - |
dc.subject.keywordPlus | Composite nanofibers | - |
dc.subject.keywordPlus | Electrospinning process | - |
dc.subject.keywordPlus | Hippocampal neurons | - |
dc.subject.keywordPlus | Neural tissue engineering | - |
dc.subject.keywordPlus | Neuronal differentiation | - |
dc.subject.keywordPlus | Physico-chemical and mechanical properties | - |
dc.subject.keywordPlus | Two Dimensional (2 D) | - |
dc.subject.keywordPlus | Neurons | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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